Impact of medication use on olfactory performance in older adults

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dc.contributor.authorIzco-Cubero, Maite
dc.contributor.authorZambom Ferraresi, Fabíola
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorFernández González de la Riva, María Luisa
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorLachén Montes, Mercedes
dc.contributor.authorLasarte, Juan José
dc.contributor.authorUzcanga Lacabe, María Iciar
dc.contributor.authorFernández, Secundino
dc.contributor.authorSanjurjo San Martín, Gloria
dc.contributor.authorMaravi Aznar, Enrique
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2025-07-28T15:13:39Z
dc.date.available2025-07-28T15:13:39Z
dc.date.issued2025-04-03
dc.date.updated2025-07-28T14:52:16Z
dc.description.abstractIntroduction: Olfactory dysfunction impacts quality of life, safety, and nutrition. Despite its relevance among older adults, the role of medications in influencing olfactory performance remains understudied. This research investigates whether olfactory alterations in older adults are associated with the type or number of medications prescribed. Methods: An observational cross-sectional study was conducted with 107 participants (mean age of 86.1 ± 5.1 years). Olfactory performance was evaluated using the Sniffin’ Sticks Test (SST). Functional capacity, cognitive function and the number and type of medications were also assessed. Results: The analysis demonstrated a correlation between better olfactory performance and higher cognitive function. An inverse correlation was found between the age of participants and olfactory identification. While polypharmacy (intake of five or more medications) did not show a significant association with olfactory dysfunction, the intake of laxatives was associated with poorer olfactory threshold performance (−1.21, 95% CI −2.07 to −0.34; p = 0.008). In contrast, proton pump inhibitors (PPIs) (1.14, 95% CI 0.07 to 2.21; p = 0.04) and vitamin D (1.09, 95% CI 0.03 to 2.15; p = 0.04) intake were linked to improved olfactory identification. Discussion: These findings suggest that certainmedications influence olfactory performance; however, further research is needed to clarify the effects of different drug classes on olfaction.en
dc.description.sponsorshipThe Clinical Neuroproteomics Unit is member of the Spanish Olfactory Network -ROE (grant RED2022-134081-T from the Spanish Ministry of Science & Innovation) and is supported by grants PID2023-152593OB-I00 funded by MCIU/AEI/ 10.13039/501100011033 / FEDER, UE to and 0011-1411-2023-000028 from Government of Navarra (Department of Economic and Business Development-S4).
dc.format.mimetypeapplication/pdf
dc.identifier.citationIzco-Cubero, M., Zambom-Ferraresi, F., Zambom-Ferraresi, F., Fernández González de la Riva, M. L., Santamaría, E., Fernandez-Irigoyen, J., Lachén-Montes, M., Lasarte, J. J., Uzcanga-Lacabe, M., Fernandez, S., Sanjurjo San Martin, G., Maraví-Aznar, E., Martinez-Velilla, N. (2025) Impact of medication use on olfactory performance in older adults. Frontiers in Public Health, 13, 1-7. https://doi.org/10.3389/fpubh.2025.1554459.
dc.identifier.doi10.3389/fpubh.2025.1554459
dc.identifier.issn2296-2565
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54481
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofFrontiers in Public Health 2025, 13:1554459, 1-7
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI//RED2022-134081-T/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-152593OB-I00/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1411-2023-000028/
dc.relation.publisherversionhttps://doi.org/10.3389/fpubh.2025.1554459
dc.rights© 2025 Izco-Cubero, Zambom-Ferraresi, Zambom-Ferraresi, de la Riva, Santamaría, Fernandez-Irigoyen, Lachén-Montes, Lasarte, Uzcanga-Lacabe, Fernandez, Martin, Maraví-Aznar and Martinez-Velilla. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectOlder peopleen
dc.subjectOlfactory disordersen
dc.subjectMedicationen
dc.subjectOlfactionen
dc.subjectPolypharmacyen
dc.subjectOlfactory dysfunctionen
dc.subjectAgeingen
dc.titleImpact of medication use on olfactory performance in older adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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