Metabolic health, mitochondrial fitness, physical activity, and cancer
| dc.contributor.author | Clemente Suárez, Vicente Javier | |
| dc.contributor.author | Martín Rodríguez, Alexandra | |
| dc.contributor.author | Redondo Flórez, Laura | |
| dc.contributor.author | Ruisoto Palomera, Pablo | |
| dc.contributor.author | Navarro Jiménez, Eduardo | |
| dc.contributor.author | Ramos Campo, Domingo Jesús | |
| dc.contributor.author | Tornero Aguilera, José Francisco | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.date.accessioned | 2023-02-17T07:55:02Z | |
| dc.date.available | 2023-02-17T07:55:02Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2023-02-17T07:45:30Z | |
| dc.description.abstract | Cancer continues to be a significant global health issue. Traditional genetic-based approaches to understanding and treating cancer have had limited success. Researchers are increasingly exploring the impact of the environment, specifically inflammation and metabolism, on cancer development. Examining the role of mitochondria in this context is crucial for understanding the connections between metabolic health, physical activity, and cancer. This study aimed to review the literature on this topic through a comprehensive narrative review of various databases including MedLine (PubMed), Cochrane (Wiley), Embase, PsychINFO, and CinAhl. The review highlighted the importance of mitochondrial function in overall health and in regulating key events in cancer development, such as apoptosis. The concept of “mitochondrial fitness” emphasizes the crucial role of mitochondria in cell metabolism, particularly their oxidative functions, and how proper function can prevent replication errors and regulate apoptosis. Engaging in high-energy-demanding movement, such as exercise, is a powerful intervention for improving mitochondrial function and increasing resistance to environmental stressors. These findings support the significance of considering the role of the environment, specifically inflammation and metabolism, in cancer development and treatment. Further research is required to fully understand the mechanisms by which physical activity improves mitochondrial function and potentially reduces the risk of cancer. | en |
| dc.description.sponsorship | Funded by the European Union—“NextGeneration EU” through the Grant for the Requalification of the Spanish University System for 2021–2023 at the Public University of Navarra (Resolution 1402/2021). | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Clemente-Suárez, V. J., Martín-Rodríguez, A., Redondo-Flórez, L., Ruisoto, P., Navarro-Jiménez, E., Ramos-Campo, D. J., & Tornero-Aguilera, J. F. (2023). Metabolic Health, Mitochondrial Fitness, Physical Activity, and Cancer. Cancers, 15(3), 814. https://doi.org/10.3390/cancers15030814 | en |
| dc.identifier.doi | 10.3390/cancers15030814 | |
| dc.identifier.issn | 2072-6694 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/44737 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | en |
| dc.relation.ispartof | Cancers 2023, 15, 814 | en |
| dc.relation.publisherversion | https://doi.org/10.3390/cancers15030814 | |
| dc.rights | © 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Metabolism | en |
| dc.subject | Mitochondria | en |
| dc.subject | Oxidative stress | en |
| dc.subject | Inflammation | en |
| dc.subject | Physical activity | en |
| dc.title | Metabolic health, mitochondrial fitness, physical activity, and cancer | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 67d90c33-1a8d-4a17-b259-940ae5d3674a | |
| relation.isAuthorOfPublication.latestForDiscovery | 67d90c33-1a8d-4a17-b259-940ae5d3674a |