Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors
| dc.contributor.author | Soto de León, Sara | |
| dc.contributor.author | Camargo, Milena | |
| dc.contributor.author | Sánchez, Ricardo | |
| dc.contributor.author | Muñoz Bobo, Marina | |
| dc.contributor.author | Pérez Prados, Antonio | |
| dc.contributor.author | Purroy Unanua, Antonio | |
| dc.contributor.author | Patarroyo, Manuel Elkin | |
| dc.contributor.author | Patarroyo, Manuel Alfonso | |
| dc.contributor.department | Matemáticas | es_ES |
| dc.contributor.department | Matematika | eu |
| dc.date.accessioned | 2014-05-29T08:11:48Z | |
| dc.date.available | 2014-05-29T08:11:48Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | Background: Infection with multiple types of human papillomavirus (HPV) is one of the main risk factors associated with the development of cervical lesions. In this study, cervical samples collected from 1, 810 women with diverse sociocultural backgrounds, who attended to their cervical screening program in different geographical regions of Colombia, were examined for the presence of cervical lesions and HPV by Papanicolau testing and DNA PCR detection, respectively. Principal Findings: The negative binomial distribution model used in this study showed differences between the observed and expected values within some risk factor categories analyzed. Particularly in the case of single infection and coinfection with more than 4 HPV types, observed frequencies were smaller than expected, while the number of women infected with 2 to 4 viral types were higher than expected. Data analysis according to a negative binomial regression showed an increase in the risk of acquiring more HPV types in women who were of indigenous ethnicity (+37.8%), while this risk decreased in women who had given birth more than 4 times (-31.1%), or were of mestizo (-24.6%) or black (-40.9%) ethnicity. Conclusions: According to a theoretical probability distribution, the observed number of women having either a single infection or more than 4 viral types was smaller than expected, while for those infected with 2-4 HPV types it was larger than expected. Taking into account that this study showed a higher HPV coinfection rate in the indigenous ethnicity, the role of underlying factors should be assessed in detail in future studies. | en |
| dc.description.sponsorship | This project was funded by Asociacion Investigacion Solidaria SADAR, Caja Navarra (Navarra, Spain) and the Spanish Agency for International Development Cooperation (AECID) (Project 08-CAP2-0609). | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.1371/journal.pone.0014705 | |
| dc.identifier.issn | 1932-6203 (Electronic) | |
| dc.identifier.other | 589 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/10651 | |
| dc.language.iso | eng | en |
| dc.publisher | Public Library of Science | en |
| dc.relation.ispartof | Plos One, 2011, 6(2): e14705 | en |
| dc.relation.publisherversion | https://dx.doi.org/10.1371/journal.pone.0014705 | |
| dc.rights | © 2011 Soto-De Leon et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
| dc.subject | Invasive cervical cancer | en |
| dc.subject | HPV infection | en |
| dc.subject | Genetic susceptibility | en |
| dc.subject | University students | en |
| dc.subject | African american | en |
| dc.subject | PCR detection | en |
| dc.subject | Primer sets | en |
| dc.subject | Women | en |
| dc.subject | Epidemiology | en |
| dc.subject | Prevalence | en |
| dc.title | Distribution patterns of infection with multiple types of human papillomaviruses and their association with risk factors | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
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