Network analysis of neurobehavioral symptom patterns in an international sample of spanish-speakers with a history of COVID-19 and controls

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dc.contributor.authorPerrin, Paul B.
dc.contributor.authorRamos Usuga, Daniela
dc.contributor.authorWest, Samuel J.
dc.contributor.authorMerced, Kritzia
dc.contributor.authorKlyce, Daniel W.
dc.contributor.authorLequerica, Anthony H.
dc.contributor.authorOlabarrieta Landa, Laiene
dc.contributor.authorAlzueta, Elisabet
dc.contributor.authorBaker, Fiona C.
dc.contributor.authorIacovides, Stella
dc.contributor.authorCortes, Mar
dc.contributor.authorArango Lasprilla, Juan Carlos
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2023-03-31T10:18:16Z
dc.date.available2023-03-31T10:18:16Z
dc.date.issued2023
dc.date.updated2023-03-31T09:59:50Z
dc.description.abstractBackground: Psychometric network analysis provides a novel statistical approach allowing researchers to model clusters of related symptoms as a dynamic system. This study applied network analysis to investigate the patterns of somatic, cognitive, and affective neurobehavioral symptoms in an international sample of Spanish-speaking individuals with a history of COVID-19 positivity and non-COVID controls; (2) methods: the sample (n = 1093) included 650 adults from 26 countries who reported having previously tested positive for COVID-19 (COVID+) through a viral and/or antigen test (average of 147 days since diagnosis). The control group (COVID−) was comprised of 443 adults from 20 countries who had completed the survey prior to the COVID19 pandemic; (3) results: relative to the COVID− network, the COVID+ network was very wellconnected, such that each neurobehavioral symptom was positively connected to the network. The organize-to-headache and dizzy-to-balance connections in the COVID+ network were stronger than in the COVID− network. The hearing, numbness, and tense symptoms were more central to the COVID+ network with the latter connected to the sleep, fatigue, and frustrated symptoms. The COVID− network was largely disjointed, with most of the somatosensory symptoms forming their own cluster with no connections to other symptom groups and fatigue not being connected to any other symptom. The cognitive and affective symptoms in the COVID− network were also largely connected to symptoms from within their own groups; (4) conclusions: These findings suggest that many of the long-term neurobehavioral symptoms of COVID-19 form a discernable network and that headaches, frustration, hearing problems, forgetfulness, and tension are the most central symptoms. Cognitive and behavioral rehabilitation strategies targeting these central symptom network features may hold promise to help fracture the lingering symptom network of COVID-19.en
dc.description.sponsorshipDaniela Ramos Usuga was supported by a predoctoral fellowship from the Basque Government (PRE_2019_1_0164). The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the Public University of Navarra (PI-003/21).en
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dc.format.mimetypeapplication/zipen
dc.identifier.citationPerrin, P. B., Ramos-Usuga, D., West, S. J., Merced, K., Klyce, D. W., Lequerica, A. H., Olabarrieta-Landa, L., Alzueta, E., Baker, F. C., Iacovides, S., Cortes, M., Arango-Lasprilla, J. C. (2023) Network analysis of neurobehavioral symptom patterns in an international sample of spanish-speakers with a history of COVID-19 and controls. International Journal of Environmental Research and Public Health, 20(1), 1-11. https://doi.org/10.3390/ijerph20010183.en
dc.identifier.doi10.3390/ijerph20010183
dc.identifier.issn1661-7827
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45000
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofInternational Journal of Environmental Research and Public Health 2023, 20, 183en
dc.relation.publisherversionhttps://doi.org/10.3390/ijerph20010183
dc.rights© 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19en
dc.subjectLong-COVIDen
dc.subjectNetwork analysisen
dc.subjectNeurobehavioral symptomsen
dc.subjectSARS-CoV-2en
dc.titleNetwork analysis of neurobehavioral symptom patterns in an international sample of spanish-speakers with a history of COVID-19 and controlsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryf893b2b6-98c4-4fcc-b6e2-b80494f50a9c

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