Prognostic relevance of preoperative immune, inflammatory, and nutritional biomarkers in patients undergoing gastrectomy for resectable gastric adenocarcinoma: an observational multicentre study

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dc.contributor.authorTur-Martínez, Jaume
dc.contributor.authorRodríguez-Santiago, Joaquín
dc.contributor.authorOsorio, Javier
dc.contributor.authorMiró, Mònica
dc.contributor.authorYárnoz Irazábal, María Concepción
dc.contributor.authorJofra, Mariona
dc.contributor.authorFerret, Georgina
dc.contributor.authorSalvador-Roses, Helena
dc.contributor.authorFernández-Ananín, Sonia
dc.contributor.authorClavell, Arantxa
dc.contributor.authorLuna, Alexis
dc.contributor.authorAldeano, Aurora
dc.contributor.authorOlona, Carles
dc.contributor.authorHermoso, Judith
dc.contributor.authorGüell-Farré, Mercè
dc.contributor.authorDal Cero, Mariagiulia
dc.contributor.authorGimeno, Marta
dc.contributor.authorPallarès, Natàlia
dc.contributor.authorPera, Manuel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-10-29T19:00:25Z
dc.date.available2024-10-29T19:00:25Z
dc.date.issued2024-06-11
dc.date.updated2024-10-29T18:51:40Z
dc.description.abstractBackground: The aim of this study was to evaluate different preoperative immune, inflammatory, and nutritional scores and their best cut-off values as predictors of poorer overall survival (OS) and disease-free survival (DFS) in patients who underwent curative gastric cancer resection. Methods: This was a retrospective observational multicentre study based on data of the Spanish EURECCA Esophagogastric Cancer Registry. Time-dependent Youden index and log-rank test were used to obtain the best cut-offs of 18 preoperative biomarkers for OS and DFS. An adjusted Cox model with variables selected by bootstrapping was used to identify the best preoperative biomarkers, which were also analysed for every TNM stage. Results: High neutrophil-to-lymphocyte ratio (NLR), high monocyte systemic inflammation index (moSII), and low prognostic nutritional index (PNI) were identified as independent predictors of poor outcome: NLR > 5.91 (HR:1.73; 95%CI [1.23–2.43]), moSII >2027.12 (HR:2.26; 95%CI [1.36–3.78]), and PNI >40.31 (HR:0.75; 95%CI [0.58–0.96]) for 5-year OS and NLR > 6.81 (HR:1.75; 95%CI [1.24–2.45]), moSII > 2027.12 (HR:2.46; 95%CI [1.49–4.04]), and PNI > 40.31 (HR:0.77; 95%CI [0.60,0.97]) for 5-year DFS. These outcomes were maintained in the whole cohort for NLR and moSII (p < 0.05) but not in stage II and for PNI in all tumoral stages. The associations of NLR-PNI and moSII-PNI were also a relevant prognostic factor for OS. Conclusions: High NLR, high moSII (for stages I and III), and low PNI (regardless of tumour stage) were the most promising preoperative biomarkers to predict poor OS and DFS in gastric cancer patients treated with curative intent.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationTur-Martínez, J., Rodríguez-Santiago, J., Osorio, J., Miró, M., Yarnoz, C., Jofra, M., Ferret, G., Salvador-Roses, H., Fernández-Ananín, S., Clavell, A., Luna, A., Aldeano, A., Olona, C., Hermoso, J., Güell-Farré, M., Dal Cero, M., Gimeno, M., Pallarès, N., Pera, M. (2024) Prognostic relevance of preoperative immune, inflammatory, and nutritional biomarkers in patients undergoing gastrectomy for resectable gastric adenocarcinoma: an observational multicentre study. Cancers, 16(12), 1-17. https://doi.org/10.3390/cancers16122188.
dc.identifier.doi10.3390/cancers16122188
dc.identifier.issn2072-6694
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52396
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofCancers 2024, 16(12), 2188
dc.relation.publisherversionhttps://doi.org/10.3390/cancers16122188
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectGastric canceren
dc.subjectPreoperative biomarkeren
dc.subjectPreoperative immune scoreen
dc.subjectPreoperative inflammation scoreen
dc.subjectPreoperative nutritional scoreen
dc.titlePrognostic relevance of preoperative immune, inflammatory, and nutritional biomarkers in patients undergoing gastrectomy for resectable gastric adenocarcinoma: an observational multicentre studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationa12183e4-f32e-413a-9cc1-56de1dbbc9e5
relation.isAuthorOfPublication.latestForDiscoverya12183e4-f32e-413a-9cc1-56de1dbbc9e5

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