Early life factors and white matter microstructure in children with overweight and obesity: the ActiveBrains project

Solís Urra, Patricio; Esteban Cornejo, Irene; Rodríguez Ayllon, María; Verdejo Román, Juan; Labayen Goñi, Idoia; Catena, Andrés; Ortega, Francisco B.

Early life factors and white matter microstructure in children with overweight and obesity: the ActiveBrains project

dc.contributor.author	Solís Urra, Patricio
dc.contributor.author	Esteban Cornejo, Irene
dc.contributor.author	Rodríguez Ayllon, María
dc.contributor.author	Verdejo Román, Juan
dc.contributor.author	Labayen Goñi, Idoia
dc.contributor.author	Catena, Andrés
dc.contributor.author	Ortega, Francisco B.
dc.contributor.department	Institute on Innovation and Sustainable Development in Food Chain - ISFOOD	en
dc.date.accessioned	2022-04-06T11:59:46Z
dc.date.available	2022-04-06T11:59:46Z
dc.date.issued	2022
dc.description.abstract	Background & aims: exposure to a suboptimal environment during the fetal and early infancy period's results in long-term consequences for brain morphology and function. We investigated the associations of early life factors such as anthropometric neonatal data (i.e., birth length, birth weight and birth head circumference) and breastfeeding practices (i.e., exclusive and any breastfeeding) with white matter (WM) microstructure, and ii) we tested whether WM tracts related to early life factors are associated with academic performance in children with overweight/obesity. Methods: 96 overweight/obese children (10.03 ± 1.16 years; 38.7% girls) were included from the ActiveBrains Project. WM microstructure indicators used were fractional anisotropy (FA) and mean diffusivity (MD), derived from Diffusion Tensor Imaging. Academic performance was evaluated with the Battery III Woodcock–Muñoz Tests of Achievement. Regression models were used to examine the associations of the early life factors with tract-specific FA and MD, as well as its association with academic performance. Results: head circumference at birth was positively associated with FA of the inferior fronto-occipital fasciculus tract (0.441; p = 0.005), as well as negatively associated with MD of the cingulate gyrus part of cingulum (−0.470; p = 0.006), corticospinal (−0.457; p = 0.005) and superior thalamic radiation tract (−0.476; p = 0.001). Association of birth weight, birth length and exclusive breastfeeding with WM microstructure did not remain significant after false discovery rate correction. None tract related to birth head circumference was associated with academic performance (all p > 0.05). Conclusions: our results highlighted the importance of the perinatal growth in WM microstructure later in life, although its possible academic implications remain inconclusive.	en
dc.description.sponsorship	This study was supported by the Spanish Ministry of Economy and Competitiveness (DEP2013 -47540 , DEP2016-79512-R, and DEP2017-91544-EXP), the European Regional Development Fund, the European Commission (No 667302 ) and the Alicia Koplowitz Foundation. This study was partially funded by the UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme. Units of Scientific Excellence; Scientific Unit of Excellence on Exercise and Health (UCEES) and by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN I+D+I 2017-2021 (Spain). Additional funding was obtained from the Andalusian Operational Programme supported with European Regional Development Funds (ERDF in English, FEDER in Spanish, project ref: B-CTS-355-UGR18). PS-U is supported by a grant from ANID /BECAS Chile/72180543. IE-C is supported by the Spanish Ministries of Economy and Competitiveness (RTI2018-095284-J-100), and Science and Innovation (RYC2019-027287-I). JV-R is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FJCI -2017-33396). Funding for open access charge: Universidad de Granada / CBUA.	en
dc.format.extent	9 p.
dc.format.mimetype	application/pdf	en
dc.identifier.doi	10.1016/j.clnu.2021.10.022
dc.identifier.issn	0261-5614
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/42634
dc.language.iso	eng	en
dc.publisher	Elsevier
dc.relation.ispartof	Clinical Nutrition, vol. 41 (1), January 2022, p. 40-48
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//DEP2013-47540-R/ES/
dc.relation.projectID	info:eu-repo/grantAgreement/ES/1PE/DEP2016-79512-R/
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//DEP2017-91544-EXP/
dc.relation.projectID	info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/667302/
dc.relation.projectID	info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095284-J-I00/ES/
dc.relation.projectID	info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2019-027287-I/
dc.relation.projectID	info:eu-repo/grantAgreement/MICIU/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJCI-2017-33396/
dc.relation.publisherversion	https://doi.org/10.1016/j.clnu.2021.10.022
dc.rights	© 2021 The Author(s). Creative Commons Attribution 4.0 International	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Academic achievement	en
dc.subject	Birth weight	en
dc.subject	Childhood	en
dc.subject	White matter	en
dc.title	Early life factors and white matter microstructure in children with overweight and obesity: the ActiveBrains project	en
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Publication
relation.isAuthorOfPublication	b36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscovery	b36e2b1d-3088-4089-806e-fd3040e9583a