Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial

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dc.contributor.authorSánchez Sánchez, Juan Luis
dc.contributor.authorSouto Barreto, Philipe de
dc.contributor.authorAntón Rodrigo, Iván
dc.contributor.authorRamón Espinoza, Fernanda
dc.contributor.authorMarín Epelde, Itxaso
dc.contributor.authorSánchez Latorre, Marina
dc.contributor.authorMoral Cuesta, Débora
dc.contributor.authorCasas Herrero, Álvaro
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.date.accessioned2023-03-27T08:21:13Z
dc.date.available2023-03-27T08:21:13Z
dc.date.issued2022
dc.date.updated2023-03-27T08:04:13Z
dc.description.abstractIntroduction: The World Health Organisation recently defined the construct of intrinsic capacity (IC), a function-based marker of older adult’s health encompassing all mental and physical capacities of the individual. Multicomponent physical exercise (MCE) is a potential intervention capable to maintain/increase IC at older age; however, evidence is scarce on the effects of MCE on IC in cognitively impaired pre-frail/frail older adults. Methods: Secondary analyses of a randomised clinical trial. One hundred and eighty-eight older outpatients (age = 84.06 ± 4.77, 70.2% women) presenting with pre-frailty/frailty (according to Fried Criteria) and mild cognitive impairment (MCI)/mild dementia were recruited in the Geriatric clinics of three tertiary hospitals in Spain. Subjects were randomised to participate in the 12-week home-based individualised Vivifrail MCE or usual care. An IC index was created based on the z-score of the locomotion (Short Physical Performance Battery), cognitive (Montreal Cognitive Assessment), psychology (15-item Geriatric Depression Scale Yesavage) and vitality (handgrip strength) domains. Results: After the 3-month intervention, linear mixed models showed significant between-group differences in the evolution of the IC composite score (β=0.48; 95% confidence interval [CI] = 0.24, 0.74; P < 0.001), IC Locomotion (β = 0.42; 95% CI = 0.10, 0.74; P < 0.001), IC Cognition (β = 0.45; 95% CI = 0.03, 0.87; P < 0.05) and IC Vitality domains (β = 0.50; 95% CI = 0.25, 0.74 at 3-month) favouring the MCE group. Conclusions: The 12-week Vivifrail multicomponent exercise program is an effective strategy to enhance IC, especially in terms of locomotion, cognition and vitality IC domains in community-dwelling older adults with pre-frailty/frailty and MCI/mild dementia, compared to usual care.en
dc.description.sponsorshipThis study has been funded by a Gobierno de Navarra project grant and FEDER Funds (426/2016,del 30 September28/16).en
dc.format.mimetypeapplication/msworden
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSánchez-Sánchez, J. L., De Souto Barreto, P., Antón-Rodrigo, I., Ramón-Espinoza, F., Marín-Epelde, I., Sánchez-Latorre, M., Moral-Cuesta, D., & Casas-Herrero, Á. (2022). Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: Secondary analysis of a multicentre randomised clinical trial. Age and Ageing, 51(12), afac303. https://doi.org/10.1093/ageing/afac303en
dc.identifier.doi10.1093/ageing/afac303
dc.identifier.issn0002-0729
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/44938
dc.language.isoengen
dc.publisherOxford University Pressen
dc.relation.ispartofAge and Ageing 2022; 51: 1–10en
dc.relation.publisherversionhttps://doi.org/10.1093/ageing/afac303
dc.rights© The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCommunity-dwellingen
dc.subjectExerciseen
dc.subjectFunctional abilityen
dc.subjectIntrinsic capacityen
dc.subjectOlder adultsen
dc.subjectOlder peopleen
dc.titleEffects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationed9d4f53-b734-4d6e-b1b9-188a148f9a13
relation.isAuthorOfPublication67dfcd6b-a693-478c-98be-f4b7c5bed42d
relation.isAuthorOfPublication.latestForDiscoveryed9d4f53-b734-4d6e-b1b9-188a148f9a13

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