Publication: Effect of insulin-like growth factor-I on nitrogen balance and intestinal galactose transport in rats with moderate liver cirrhosis
| dc.contributor.author | Núñez, Marina | |
| dc.contributor.author | Urdaneta, Elena | |
| dc.contributor.author | Santidrián, Santiago | |
| dc.contributor.department | Ciencias del Medio Natural | es_ES |
| dc.contributor.department | Natura Ingurunearen Zientziak | eu |
| dc.date.accessioned | 2019-01-16T08:07:55Z | |
| dc.date.available | 2019-01-16T08:07:55Z | |
| dc.date.issued | 2003 | |
| dc.description.abstract | The malnutrition caused by liver cirrhosis (LC) often worsens the course of the disease. Patients affected by LC often have a low bioavailability of the anabolic liver peptide insulin-like growth factor (IGF)-I. The present study was undertaken to investigate the effect of low doses of IGF-I on the nutritional status and in vivo jejunal transport of d-galactose in anatomically, pathologically and biochemically confirmed moderate, non-ascitic, cirrhotic rats. LC was experimentally induced in growing rats by inhalation of CCl4 and addition of phenobarbital to drinking water. Both the nutritional status, as evaluated by N balance, and in vivo intestinal transport of d-galactose, were significantly impaired in cirrhotic rats. As compared with healthy rats, administration of 20μg human recombinant IGF-I/kg body weight for 14d to cirrhotic rats significantly improved N balance variables and restored in vivo intestinal transport of the sugar. However, IGF-I had no effect on the steatorrhoea associated with LC. These results suggest that low doses of IGF-I may have beneficial effects on the malnutrition associated with moderate LC. | en |
| dc.format.extent | 9 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.1079/bjn2003974 | |
| dc.identifier.issn | 0007-1145 (Print) | |
| dc.identifier.issn | 1475-2662 (Electronic) | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/31970 | |
| dc.language.iso | eng | en |
| dc.publisher | Cambridge University Press | en |
| dc.relation.ispartof | British Journal of Nutrition (2003), 90, 929–937 | en |
| dc.relation.publisherversion | https://doi.org/10.1079/bjn2003974 | |
| dc.rights | © The Authors 2003 | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.subject | Effect of insulin-like growth factor-I | en |
| dc.subject | Nitrogen balance | en |
| dc.subject | Intestinal absorption | en |
| dc.subject | Cirrhosis | en |
| dc.subject | Rats | en |
| dc.title | Effect of insulin-like growth factor-I on nitrogen balance and intestinal galactose transport in rats with moderate liver cirrhosis | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | en |
| dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
| dspace.entity.type | Publication |