Right bundle branch block predicts appropriate implantable cardioverter defibrillator therapies in patients with non-Iischemic dilated cardiomyopathy and a prophylactic implantable cardioverter defibrillator
| dc.contributor.author | Jiménez-Blanco Bravo, Marta | |
| dc.contributor.author | Alonso Salinas, Gonzalo Luis | |
| dc.contributor.author | Parra Esteban, Carolina | |
| dc.contributor.author | Toquero Ramos, Jorge | |
| dc.contributor.author | Amores Luque, Miguel | |
| dc.contributor.author | Zamorano Gómez, José Luis | |
| dc.contributor.author | García-Izquierdo, Eusebio | |
| dc.contributor.author | Álvarez-García, Jesús | |
| dc.contributor.author | Fernández Lozano, Ignacio | |
| dc.contributor.author | Castro Urda, Víctor | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.date.accessioned | 2024-10-24T14:34:08Z | |
| dc.date.available | 2024-10-24T14:34:08Z | |
| dc.date.issued | 2024-06-01 | |
| dc.date.updated | 2024-10-24T14:23:37Z | |
| dc.description.abstract | Background: the benefit of prophylactic implantable cardioverter defibrillators (ICDs) in patients with severe systolic dysfunction of non-ischemic origin is still unclear, and the identification of patients at risk for sudden cardiac death remains a major challenge. Aims/Methods: we retrospectively reviewed all consecutive patients with non-ischemic dilated cardiomyopathy (NICM) who underwent prophylactic ICD implantation between 2008 and 2020 in two tertiary centers. Our main goal was to identify the predictors of appropriate ICD therapies (anti-tachycardia pacing [ATP] and/or shocks) in this cohort of patients. Results: a total of 224 patients were included. After a median follow-up of 51 months, 61 patients (27.2%) required appropriate ICD therapies. Patients with appropriate ICD therapies were more frequently men (87% vs. 69%, p = 0.006), of younger age (59 years, (53-65) vs. 64 years, (57-70); p = 0.02), showed more right bundle branch blocks (RBBBs) (15% vs. 4%, p = 0.007) and less left bundle branch blocks (LBBBs) (26% vs. 47%, p = 0.005) in the ECG, and had higher left ventricular end-diastolic (100 mL/m2, (90-117) vs. 86, (71-110); p = 0.011) and systolic volumes (72 mL/m2, (59-87) vs. 61, (47-81), p = 0.05). In a multivariate competing-risks regression analysis, RBBB (HR 2.26, CI 95% 1.02-4.98, p = 0.043) was identified as an independent predictor of appropriate ICD therapies. Conclusion: RBBBs may help to identify patients with NICM at high risk of ventricular arrhythmias and requiring ICD intervention. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Jiménez-Blanco Bravo, M., Alonso Salinas, G. L., Parra Esteban, C., Toquero Ramos, J., Amores Luque, M., Zamorano Gómez, J. L., García-Izquierdo, E., Álvarez-García, J., Fernández Lozano, I., Castro Urda, V. (2024) Right bundle branch block predicts appropriate implantable cardioverter defibrillator therapies in patients with non-Iischemic dilated cardiomyopathy and a prophylactic implantable cardioverter defibrillator. Diagnostics, 14(11), 1-10. https://doi.org/10.3390/diagnostics14111173. | |
| dc.identifier.doi | 10.3390/diagnostics14111173 | |
| dc.identifier.issn | 2075-4418 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/52374 | |
| dc.language.iso | eng | |
| dc.publisher | MDPI | |
| dc.relation.ispartof | Diagnostics 2024, 14(11), 1173 | |
| dc.relation.publisherversion | https://doi.org/10.3390/diagnostics14111173 | |
| dc.rights | © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license. | |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Implantable cardioverter defibrillator | en |
| dc.subject | Non-ischemic dilated cardiomyopathy | en |
| dc.subject | Primary prevention | en |
| dc.subject | Right bundle branch block | en |
| dc.subject | Sudden cardiac death | en |
| dc.title | Right bundle branch block predicts appropriate implantable cardioverter defibrillator therapies in patients with non-Iischemic dilated cardiomyopathy and a prophylactic implantable cardioverter defibrillator | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 19594984-6f7d-48a8-88f0-b5e35ccebb77 | |
| relation.isAuthorOfPublication.latestForDiscovery | 19594984-6f7d-48a8-88f0-b5e35ccebb77 |