Neurocognitive correlates of the varied domains of outcomes at 20 year follow-up of first-episode psychosis
| dc.contributor.author | Cuesta, Manuel J. | |
| dc.contributor.author | Sánchez-Torres, A. M. | |
| dc.contributor.author | Moreno-Izco, Lucía | |
| dc.contributor.author | García de Jalón, Elena | |
| dc.contributor.author | Gil Berrozpe, Gustavo José | |
| dc.contributor.author | Zarzuela, Amalia | |
| dc.contributor.author | Peralta Martín, Víctor | |
| dc.contributor.author | SEGPEPs Group | |
| dc.contributor.author | Sánchez Torres, Ana María | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua | |
| dc.date.accessioned | 2025-03-18T09:51:15Z | |
| dc.date.available | 2025-03-18T09:51:15Z | |
| dc.date.issued | 2022-11-02 | |
| dc.date.updated | 2025-03-18T09:47:54Z | |
| dc.description.abstract | Little is known about long-term outcomes of the first episode of psychosis (FEP) other than in the symptomatic domain. We hypothesised that cognitive impairment is associated with poorer multi-domain outcomes at a long-term follow-up of FEP patients. We followed-up 172 FEP patients for a mean of 20.3 years. Ten outcome dimensions were assessed (symptomatic, functional and personal recovery, social disadvantage, physical health, suicide attempts, number of episodes, current drug use, chlorpromazine equivalent doses (CPZ), and schizophrenia/schizoaffective disorder final diagnosis). Cognition was assessed at follow-up. Processing speed and verbal memory deficits showed significant associations with poor outcomes on symptomatic, social functioning, social disadvantage, higher number of episodes, and higher CPZ. Significant associations were found between visual memory impairments were significantly associated with low symptomatic and functional recovery, between attentional deficits and a final diagnosis of schizophrenia/schizoaffective disorder, and between social cognition deficits and poor personal recovery.Lower cognitive global scores were significantly associated with all outcome dimensions except for drug abuse and physical status. Using multiple outcome dimensions allowed for the inclusion of the patients¿ perspective and other commonly neglected outcome measures. Taken together, cognitive impairment in FEP patients is strongly related to poor performance on several outcome dimensions beyond symptomatic remission. | |
| dc.description.sponsorship | This work was supported by the Government of Navarra (grants 17/31 and 18/41) and by the Carlos III Health Institute (FEDER Funds) from the Spanish Ministry of Economy and Competitivity (16/2148 and 19/1698). | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Cuesta, M. J., Sánchez-Torres, A. M., Moreno-Izco, L., García de Jalón, E., Gil-Berrozpe, G. J., Zarzuela, A., Peralta, V., SEGPEPs Group (2022). Neurocognitive correlates of the varied domains of outcomes at 20 year follow-up of first-episode psychosis. Psychiatry Research, 318, 1-11. https://doi.org/10.1016/j.psychres.2022.114933. | |
| dc.identifier.doi | 10.1016/j.psychres.2022.114933 | |
| dc.identifier.issn | 0165-1781 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/53763 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartof | Psychiatry Research 318 (2022) 114933 | |
| dc.relation.publisherversion | https://doi.org/10.1016/j.psychres.2022.114933 | |
| dc.rights | © 2022 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0. | |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | First episode of psychosis | |
| dc.subject | Cognition | |
| dc.subject | Recovery | |
| dc.subject | Longitudinal | |
| dc.subject | Long-term outcomes | |
| dc.title | Neurocognitive correlates of the varied domains of outcomes at 20 year follow-up of first-episode psychosis | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 6cfdb372-fb89-4760-b1b8-404b0f0ae941 | |
| relation.isAuthorOfPublication.latestForDiscovery | 6cfdb372-fb89-4760-b1b8-404b0f0ae941 |