Size effects in finite element modelling of 3D printed bone scaffolds using hydroxyapatite PEOT/PBT composites

Simple item page
dc.contributor.authorCalderón Uriszar-Aldaca, Íñigo
dc.contributor.authorPérez, Sergio
dc.contributor.authorSinha, Ravi
dc.contributor.authorCámara Torres, María
dc.contributor.authorVillanueva, Sara
dc.contributor.authorMota, Carlos
dc.contributor.authorPatelli, Alessandro
dc.contributor.authorMatanza, Amaia
dc.contributor.authorMoroni, Lorenzo
dc.contributor.authorSánchez, Alberto
dc.contributor.departmentIngenieríaes_ES
dc.contributor.departmentIngeniaritzaeu
dc.date.accessioned2022-01-18T09:18:40Z
dc.date.available2022-01-18T09:18:40Z
dc.date.issued2021
dc.description.abstractAdditive manufacturing (AM) of scaffolds enables the fabrication of customized patient-specific implants for tissue regeneration. Scaffold customization does not involve only the mac-roscale shape of the final implant, but also their microscopic pore geometry and material properties, which are dependent on optimizable topology. A good match between the experimental data of AM scaffolds and the models is obtained when there is just a few millimetres at least in one direction. Here, we describe a methodology to perform finite element modelling on AM scaffolds for bone tissue regeneration with clinically relevant dimensions (i.e., volume > 1 cm3). The simulation used an equivalent cubic eight node finite elements mesh, and the materials properties were derived both empirically and numerically, from bulk material direct testing and simulated tests on scaffolds. The experimental validation was performed using poly(ethylene oxide terephthalate)-poly(butylene ter-ephthalate) (PEOT/PBT) copolymers and 45 wt% nano hydroxyapatite fillers composites. By applying this methodology on three separate scaffold architectures with volumes larger than 1 cm3, the simulations overestimated the scaffold performance, resulting in 150–290% stiffer than average values obtained in the validation tests. The results mismatch highlighted the relevance of the lack of printing accuracy that is characteristic of the additive manufacturing process. Accordingly, a sensi-tivity analysis was performed on nine detected uncertainty sources, studying their influence. After the definition of acceptable execution tolerances and reliability levels, a design factor was defined to calibrate the methodology under expectable and conservative scenarios.en
dc.description.sponsorshipThis research was funded by the European Union, represented by the European Commission, grant number 685825-FAST-H2020-NMP-2014-2015/H2020-NMP-PILOTS-2015.en
dc.format.extent37 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.3390/math9151746
dc.identifier.issn2227-7390
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/41839
dc.language.isoengen
dc.publisherMDPIen
dc.relation.ispartofMathematics 2021, 9, 1746en
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/685825/
dc.relation.publisherversionhttp://doi.org/10.3390/math9151746
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject3D scaffolden
dc.subjectAdditive manufacturingen
dc.subjectBone tissue engineeringen
dc.subjectFinite element modellingen
dc.titleSize effects in finite element modelling of 3D printed bone scaffolds using hydroxyapatite PEOT/PBT compositesen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication48177dfc-fc7a-4f70-b84f-e8bd780c010b
relation.isAuthorOfPublication.latestForDiscovery48177dfc-fc7a-4f70-b84f-e8bd780c010b

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Calderon_SizeEffects.pdf
Size:
12.82 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DING - INGS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak
Investigaciones financiadas por la Unión Europea (OpenAire) - Europar Batasunak finantzatutako ikerketak (OpenAire)