Publication:
Nontypable haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates

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dc.contributor.authorMartí Lliteras, Pau
dc.contributor.authorLópez Gómez, Antonio
dc.contributor.authorMauro, Silvia
dc.contributor.authorHood, Derek W.
dc.contributor.authorViadas Martínez, Cristina
dc.contributor.authorCalatayud, Laura
dc.contributor.authorMorey Sancho, Pau
dc.contributor.authorServin, Alain
dc.contributor.authorLiñares, Josefina
dc.contributor.authorOliver, Antonio
dc.contributor.authorBengoechea Alonso, José Antonio
dc.contributor.authorGarmendia García, Juncal
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.date.accessioned2014-06-05T07:57:18Z
dc.date.available2014-06-05T07:57:18Z
dc.date.issued2011
dc.description.abstractNon-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the existence of a remarkable genetic variability among NTHi strains. In this study we show that, in spite of a high level of genetic heterogeneity, NTHi clinical isolates display a prevalent molecular feature, which could confer fitness during infectious processes. A total of 111 non-isogenic NTHi strains from an identical number of patients, isolated in two distinct geographical locations in the same period of time, were used to analyse nine genes encoding bacterial surface molecules, and revealed the existence of one highly prevalent molecular pattern (lgtF+, lic2A+, lic1D+, lic3A+, lic3B+, siaA-, lic2C+, ompP5+, oapA+) displayed by 94.6% of isolates. Such a genetic profile was associated with a higher bacterial resistance to serum mediated killing and enhanced adherence to human respiratory epithelial cells.en
dc.description.sponsorshipThis work was supported by grants from Instituto de Salud Carlos III (ISCIII, Spain) with references CP05-0027, PI06-1251 and PS09-0130, and from Fundación Mutua Madrileña 2008 to JG, and by a grant from Instituto de Salud Carlos III (ISCIII, Spain) with reference PS09-1904 to JL.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1371/journal.pone.0021133
dc.identifier.issn1932-6203 (electronic)
dc.identifier.other568
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/10744
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPlos One, 2011, 6(6): e21133en
dc.relation.publisherversionhttps://dx.doi.org/10.1371/journal.pone.0021133
dc.rights© 2011 Martí–Lliteras et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectOuter membrane proteinen
dc.subjectC reactive proteinen
dc.subjectEpithelial cellsen
dc.subjectOtitis mediaen
dc.subjectPhase variationen
dc.subjectBiofilm communitiesen
dc.subjectSerum resistanceen
dc.subjectSialic aciden
dc.subjectMiddle earen
dc.subjectInner coreen
dc.titleNontypable haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolatesen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublicationff1db363-7a7e-49cf-b634-e39377d421e6
relation.isAuthorOfPublication6018a4d2-1ded-494f-92de-2ca4cebbe693
relation.isAuthorOfPublication.latestForDiscoveryff1db363-7a7e-49cf-b634-e39377d421e6

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