Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins

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dc.contributor.authorTormo Más, María Ángeles
dc.contributor.authorFerrer, María Desamparados
dc.contributor.authorMaiques, Elisa
dc.contributor.authorUbeda, Carles
dc.contributor.authorSelva, Laura
dc.contributor.authorLasa Uzcudun, Íñigo
dc.contributor.authorCalvete, Juan J.
dc.contributor.authorNovick, Richard P.
dc.contributor.authorPenadés, José R.
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.date.accessioned2019-01-23T11:16:22Z
dc.date.available2019-01-23T11:16:22Z
dc.date.issued2008
dc.description.abstractStaphylococcus aureus pathogenicity islands (SaPIs) have an intimate relationship with temperate staphylococcal phages. During phage growth, SaPIs are induced to replicate and are efficiently encapsidated into special small phage heads commensurate with their size. We have analyzed by amino acid sequencing and mass spectrometry the protein composition of the specific SaPI particles. This has enabled identification of major capsid and tail proteins and a putative portal protein. As expected, all these proteins were phage encoded. Additionally, these analyses suggested the existence of a protein required for the formation of functional phage but not SaPI particles. Mutational analysis demonstrated that the phage proteins identified were involved only in the formation and possibly the function of SaPI or phage particles, having no role in other SaPI or phage functions.en
dc.description.sponsorshipThis work was supported by grant BIO2005-08399-C02-02 from the Comisión Interministerial de Ciencia y Tecnología (C.I.C.Y.T.) and grants from the Cardenal Herrera-CEU University and from the Generalitat Valenciana (ACOMP07/258) to J.R.P. Fellowship support for María Desamparados Ferrer and for Elisa Maiques from the Cardenal Herrera-CEU University is gratefully acknowledged.en
dc.format.extent7 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1128/jb.01349-07
dc.identifier.issn0021-9193(Print)
dc.identifier.issn1098-5530 (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/32087
dc.language.isoengen
dc.publisherAmerican Society for Microbiologyen
dc.relation.ispartofJournal of Bacteriology, vol. 190, nº 7 , apr. 2008, p. 2434–2440en
dc.relation.publisherversionhttps://doi.org/10.1128/jb.01349-07
dc.rights© 2008, American Society for Microbiology. All Rights Reserved.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectStaphylococcus aureusen
dc.subjectStaphylococcus Phagesen
dc.subjectViral proteinsen
dc.subjectGeneticsen
dc.titleStaphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteinsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicationc654d104-1ae2-41cf-9215-4b4bed3e5ea6
relation.isAuthorOfPublication.latestForDiscoveryc654d104-1ae2-41cf-9215-4b4bed3e5ea6

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