Epidermal growth factor receptor ligands in murine models for erythropoietic protoporphyria: potential novel players in the progression of liver injury

Simple item page
dc.contributor.authorBerasain, Carmen
dc.contributor.authorSampedro, Ana
dc.contributor.authorMauleón, I.
dc.contributor.authorGoñi Irigoyen, Saioa
dc.contributor.authorLatasa, Maria Ujue
dc.contributor.authorMatscheko, N.
dc.contributor.authorGarcía-Bravo, M.
dc.contributor.authorUnzu, Carmen
dc.contributor.authorCorrales, Fernando J.
dc.contributor.authorEnríquez de Salamanca, R.
dc.contributor.authorPrieto, Jesús
dc.contributor.authorÁvila, Matías A.
dc.contributor.authorFontanellas, Antonio
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-04-29T17:53:46Z
dc.date.available2024-04-29T17:53:46Z
dc.date.issued2009
dc.date.updated2024-04-29T16:46:02Z
dc.description.abstractActivation of the epidermal growth factor receptor (EGFR) plays an important role in liver regeneration and resistance to acute injury. However its chronic activation participates in the progression of liver disease, including fibrogenesis and malignant transformation. Hepatobiliary disease represents a constant feature in the clinically relevant Fechm1pas/Fechm1pas genetic model of erythropoietic protoporphyria (EPP). Similarly, chronic administration of griseofulvin to mice induces pathological changes similar to those found in patients with EPP-associated liver injury. We investigated the hepatic expression of the EGFR and its seven most relevant ligands in Fechm1pas/Fechm1pas mice bred in three different backgrounds, and in griseofulvin-induced protoporphyria. We observed that the expression of amphiregulin, betacellulin and epiregulin was significantly increased in young EPP mice when compared to aged-matched controls in all genetic backgrounds. The expression of these ligands was also tested in older (11 months) BALB/cJ EPP mice, and it was found to remain induced, while that of the EGFR was downregulated. Griseofulvin feeding also increased the expression of amphiregulin, betacellulin and epiregulin. Interestingly, protoporphyrin accumulation in cultured hepatic AML-12 cells readily elicited the expression of these three EGFR ligands. Our findings suggest that protoporphyrin could directly induce the hepatic expression of EGFR ligands, and that their chronic upregulation might participate in the pathogenesis of EPPassociated liver disease.en
dc.description.sponsorshipWork in the authors’ laboratory is supported by: the agreement between FIMA and the “UTE project CIMA”; Spanish Fundación Mutua Madrileña (to AF, CB, RES, FJC and MAA); Red Temática de Investigación Cooperativa en Cáncer RD06 00200061 (to CB, FJC and MAA), and CIBERehd (to JP) from Instituto de Salud Carlos III; Grants from Ministerio de Sanidad y Consumo FIS PI070392 and PI070402 (to CB and MAA); FIS PI 061475 (to AF) and FIS PI 02/1888 (to RES, AF and MGB); Grant SAF2008-0154 from Ministerio de Educación y Ciencia (to FJC). MUL and SG were supported by a Juan de la Cierva contract from MEC, and a fellowship from FIS respectively.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBerasain, C., Sampedro, A., Mauleón, I., Goñi, S., Latasa, M. U., Matscheko, N., García-Bravo, M., Unzu, C., Corrales, F. J., Enríquez de Salamanca, R., Prieto, J., Avila, M. A., Fontanellas, A. (2009) Epidermal growth factor receptor ligands in murine models for erythropoietic protoporphyria: Potential novel players in the progression of liver injury. Cellular and Molecular Biology, 55(1), 29-37. https://doi.org/10.1170/T835en
dc.identifier.doi10.1170/T835 (erróneo)
dc.identifier.issn0145-5680
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48022
dc.language.isoengen
dc.publisherCMB Associationen
dc.relation.ispartofCellular and Molecular Biology 2009, 55(1), 29-37en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MSC//PI070392/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MSC//PI070402/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//SAF2008-01540/ES/
dc.relation.publisherversionhttps://doi.org/10.1170/T835
dc.rights©2009 C.M.B. Edition. Creative Commons BY-NC 4.0 Attribution-NonCommercial 4.0 Internationalen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectErythropoietic protoporphyriaen
dc.subjectProtoporphyrinen
dc.subjectHepatobiliary diseaseen
dc.subjectAmphiregulinen
dc.subjectBetacellulinen
dc.subjectEpiregulinen
dc.subjectEpidermal growth factor receptoren
dc.titleEpidermal growth factor receptor ligands in murine models for erythropoietic protoporphyria: potential novel players in the progression of liver injuryen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication7945ddd5-cf8b-4927-bd7a-4ade2fb61f11
relation.isAuthorOfPublication.latestForDiscovery7945ddd5-cf8b-4927-bd7a-4ade2fb61f11

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2009_Berasain_protoporphyria.pdf
Size:
174.68 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.78 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista DCS - OZS Aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak