Publication: Morphological and biochemical characterization of a cell death process induced by E3, a new synthetic diarylsulfonilurea analogue
Date
2001
Authors
Miglaccio, M.
Asumendi, A.
Hilario, E.
García, M.
Director
Publisher
Hindawi
Acceso abierto / Sarbide irekia
Otros / Bestelakoak
Versión publicada / Argitaratu den bertsioa
Project identifier
Abstract
With a view to finding new compounds with improved antitumoral activity and reduced secondary effects, our group, using theoretical structure-activity studies, has designed several analogues and derivatives of diarylsulfonilureas. These compounds have been synthesized and tested “in vitro” on a panel of human tumor cell lines and showed an antitumoral activity. In the present work, we have characterized the mechanisms involved in the cell death process induced by one of these products called E3 in a CCRF-CEM cell line.
Description
Keywords
Cell death processes, E3, CCRF-CEM
Department
Ciencias de la Salud / Química Aplicada / Osasun Zientziak / Kimika Aplikatua
Faculty/School
Degree
Doctorate program
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© 2001 M. Alonso et al.
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