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The effects of selective breeding against scrapie susceptibility on the genetic variability of the latxa black-faced sheep breed

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dc.contributor.authorAlfonso Ruiz, Leopoldo
dc.contributor.authorParada Rey, Analia
dc.contributor.authorLegarra, Andrés
dc.contributor.authorUgarte, Eva
dc.contributor.authorArana Navarro, Ana
dc.contributor.departmentProducción Agrariaes_ES
dc.contributor.departmentNekazaritza Ekoizpenaeu
dc.date.accessioned2014-05-14T07:35:02Z
dc.date.available2014-05-14T07:35:02Z
dc.date.issued2006
dc.description.abstractBreeding sheep populations for scrapie resistance could result in a loss of genetic variability. In this study, the effect on genetic variability of selection for increasing the ARR allele frequency was estimated in the Latxa breed. Two sources of information were used, pedigree and genetic polymorphisms (fifteen microsatellites). The results based on the genealogical information were conditioned by a low pedigree completeness level that revealed the interest of also using the information provided by the molecular markers. The overall results suggest that no great negative effect on genetic variability can be expected in the short time in the population analysed by selection of only ARR/ARR males. The estimated average relationship of ARR/ARR males with reproductive females was similar to that of all available males whatever its genotype: 0.010 vs. 0.012 for a genealogical relationship and 0.257 vs. 0.296 for molecular coancestry, respectively. However, selection of only ARR/ARR males implied important losses in founder animals (87 percent) and low frequency alleles (30 percent) in the ram population. The evaluation of mild selection strategies against scrapie susceptibility based on the use of some ARR heterozygous males was difficult because the genetic relationships estimated among animals differed when pedigree or molecular information was used, and the use of more molecular markers should be evaluated.en
dc.description.sponsorshipFinancial support for this work was provided by the Spanish “Ministerio de Ciencia y Tecnología” (EET2001-4891-C03-3)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1051/gse:2006017
dc.identifier.issn0999-193X (print)
dc.identifier.issn1297-9686 (electronic)
dc.identifier.other823
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/10530
dc.language.isoengen
dc.publisherEDP Sciencesen
dc.relation.ispartofGenetics Selection Evolution, 2006, 38 (5). Págs. 495-511en
dc.relation.publisherversionhttps://dx.doi.org/10.1051/gse:2006017
dc.rights© Inra, EDP Sciences, 2006en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectGenetic variabilityen
dc.subjectScrapieen
dc.subjectManechen
dc.subjectLatxa sheepen
dc.subjectMolecular coancestry informationen
dc.subjectMicrosatellite analysisen
dc.subjectPedigreeen
dc.subjectInformationen
dc.subjectComputer programen
dc.subjectSpanish sheepen
dc.subjectPopulationsen
dc.subjectDiversityen
dc.subjectConservationen
dc.subjectManagementen
dc.titleThe effects of selective breeding against scrapie susceptibility on the genetic variability of the latxa black-faced sheep breeden
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión aceptada / Onetsi den bertsioaes
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublicationee903831-0350-48ee-9595-de9942e3a89b
relation.isAuthorOfPublication154be528-5612-4204-9b03-a978cd6e8555
relation.isAuthorOfPublication2b09fbbc-cd45-4ecf-afb9-dc03ac32a9f4
relation.isAuthorOfPublication.latestForDiscoveryee903831-0350-48ee-9595-de9942e3a89b

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