Short-term multicomponent exercise impact on muscle function and structure in hospitalized older at risk of acute sarcopenia

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dc.contributor.authorLópez Sáez de Asteasu, Mikel
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorGarcía Alonso, Yesenia
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorLusa Cadore, Eduardo
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2025-01-23T18:28:33Z
dc.date.available2025-01-23T18:28:33Z
dc.date.issued2024-10-13
dc.date.updated2025-01-23T18:01:23Z
dc.description.abstractBackground. Hospitalization exacerbates sarcopenia and physical dysfunction in older adults. Whether tailored inpatient exercise prevents acute sarcopenia is unknown. This study aimed to examine the effect of a multicomponent exercise programme on muscle and physical function in hospitalized older adults. We hypothesized that participation in a brief tailored exercise regimen (i.e., 3–5 days) would attenuate muscle function and structure changes compared with usual hospital care alone. Methods. This randomized clinical trial with blinded outcome assessment was conducted from May 2018 to April 2021 at Hospital Universitario de Navarra, Spain. Participants were 130 patients aged 75 years and older admitted to an acute care geriatric unit. Patients were randomized to a tailored 3- to 5-day exercise programme (n = 64) or usual hospital care (control, n = 66) consisting of physical therapy if needed. The coprimary endpoints were between-group differences in changes in short physical performance battery (SPPB) score and usual gait velocity from hospital admission to discharge. Secondary endpoints included changes in rectus femoris echo intensity, cross-sectional area, thickness and subcutaneous and intramuscular fat by ultrasound. Results. Among 130 randomized patients (mean [SD] age, 87.7 [4.6] years; 57 [44%] women), the exercise group increased their mean SPPB score by 0.98 points (95% CI, 0.28–1.69 points) and gait velocity by 0.09 m/s (95% CI, 0.03–0.15 m/s) more than controls (both p < 0.01). No between-group differences were observed in any ultrasound muscle outcomes. There were no study-related adverse events. Conclusions. Three to 5 days of tailored multicomponent exercise provided functional benefits but did not alter muscle or fat architecture compared with usual hospital care alone among vulnerable older patients. Brief exercise may help prevent acute sarcopenia during hospitalization.en
dc.description.sponsorshipThis study was funded by a Gobierno de Navarra project Resolución grant 2186/2014 and acknowledged with the 'Beca Ortiz de Landazuri' forthe best research clinical project in 2014. Additionally, this study was funded by a research grant PI17/01814 from the Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER). N.M-V received funding from the 'la Caixa' Foundation (ID 100010434), under agreement LCF/PR/PR15/51100006.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSáez de Asteasu, M. L., Martínez-Velilla, N., Zambom-Ferraresi, F., García-Alonso, Y., Galbete, A., Ramírez-Vélez, R., Cadore, E. L., Izquierdo, M. (2024) Short-term multicomponent exercise impact on muscle function and structure in hospitalized older at risk of acute sarcopenia. Journal of Cachexia, Sarcopenia and Muscle (JCSM), 15(6), 2586-2594. https://doi.org/10.1002/jcsm.13602.
dc.identifier.doi10.1002/jcsm.13602
dc.identifier.issn2190-5991
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53073
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Muscle 2024, 15(6), 2586-2594
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01814/ES/
dc.relation.publisherversionhttps://doi.org/10.1002/jcsm.13602
dc.rights© 2024 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work isproperly cited.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHospitalizationen
dc.subjectMulticomponent trainingen
dc.subjectVivifrailen
dc.titleShort-term multicomponent exercise impact on muscle function and structure in hospitalized older at risk of acute sarcopeniaen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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