Proteomics and recurrence of atrial fibrillation: a pilot study nested in the PREDIMAR trial
dc.contributor.author | Razquin, Cristina | |
dc.contributor.author | Fernández Irigoyen, Joaquín | |
dc.contributor.author | Barrio-López, María Teresa | |
dc.contributor.author | López, Begoña | |
dc.contributor.author | Ravassa, Susana | |
dc.contributor.author | Ramos, Pablo | |
dc.contributor.author | Macías-Ruiz, Rosa | |
dc.contributor.author | Ibáñez Criado, Alicia | |
dc.contributor.author | Santamaría Martínez, Enrique | |
dc.contributor.author | Goñi, Leticia | |
dc.contributor.author | Castellanos, Eduardo | |
dc.contributor.author | Ibáñez Criado, José Luis | |
dc.contributor.author | Tercedor, Luis | |
dc.contributor.author | García-Bolao, Ignacio | |
dc.contributor.author | Martínez González, Miguel Ángel | |
dc.contributor.author | Almendral, Jesús | |
dc.contributor.author | Ruiz Canela, Miguel | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua | |
dc.date.accessioned | 2025-06-30T15:41:39Z | |
dc.date.available | 2025-06-30T15:41:39Z | |
dc.date.issued | 2025-01-24 | |
dc.date.updated | 2025-06-30T15:22:29Z | |
dc.description.abstract | Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide. Although catheter ablation is the most efficacious therapy, relapses occur frequently (30%) in the first year after ablation. Novel biomarkers of recurrence are needed for a better prediction of recurrence and management of AF. In this pilot study, we aimed to analyze the baseline proteome of subjects included in a case-control study to find differential proteins associated with AF recurrence. Methods: Baseline serum proteomics (354 proteins) data from 16 cases (recurrent AF) and 17 controls (non-recurrent) were obtained using MS/MS analysis. A false discovery rate was performed using a nonlinear fitting method for the selection of proteins. Logistic regression models were used to further analyze the association between differentially expressed proteins and AF recurrence. Results: Ten proteins were differentially represented in cases vs. controls. Two were upregulated in the cases compared to the controls: keratin type I cytoskeletal 17 (Fold-change [FC] = 2.14; p = 0.017) and endoplasmic bifunctional protein (FC = 1.65; p = 0.032). Eight were downregulated in the cases compared to the controls: C4bpA (FC = 0.64; p = 0.006), coagulation factor XI (FC = 0.83; p = 0.011), CLIC1 (FC = 0.62; p = 0.017), haptoglobin (FC = 0.37; p = 0.021), Ig alpha-2 chain C region (FC = 0.49; p = 0.022), C4bpB (FC = 0.73; p = 0.028), N-acetylglucosamine-1- phosphotransferase subunit gamma (FC = 0.61; p = 0.033), and platelet glycoprotein Ib alpha chain (FC = 0.84; p = 0.038). Conclusion: This pilot study identifies ten differentially expressed serum proteins associated with AF recurrence, offering potential biomarkers for improved prediction and management. | en |
dc.description.sponsorship | This study was supported by the Spanish Government Official Agency for funding biomedical research - Instituto de Salud Carlos III (ISCIII) - with competitive grants through the Fondo de Investigación Sanitaria y Fondo Europeo de Desarrollo Regional (PI17/00718, PI17/00748, PI17/01870) and ProteoRed; the Regional Government of Navarra (46/2016); and the Spanish Society of Cardiology (FEC/2016). | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | application/zip | |
dc.identifier.citation | Razquin, C., Fernández-Irigoyen, J., Barrio-López, M. T., López, B., Ravassa, S., Ramos, P., Macías-Ruiz, R., Ibañez Criado, A., Santamaría, E., Goni, L., Castellanos, E., Ibáñez Criado, J. L., Tercedor, L., García-Bolao, I., Martínez-González, M. A., Almendral, J., Ruiz-Canela, M. (2025) Proteomics and recurrence of atrial fibrillation: a pilot study nested in the PREDIMAR trial. Lifestyle Genomics, 18(1), 52-58. https://doi.org/10.1159/000543639. | |
dc.identifier.doi | 10.1159/000543639 | |
dc.identifier.issn | 2504-3161 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/54349 | |
dc.language.iso | eng | |
dc.publisher | Karger | |
dc.relation.ispartof | Lifestyle Genomics 2025, 18(1), 52-58 | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F00718/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F00748/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01870/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/Gobierno de Navarra/// | |
dc.relation.publisherversion | https://doi.org/10.1159/000543639 | |
dc.rights | © 2025 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons AttributionNonCommercial 4.0 International License (CC BY-NC), usage and distributionfor commercial purposes requires written permission. | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
dc.subject | Proteomics | en |
dc.subject | Atrial fibrillation | en |
dc.subject | Recurrence | en |
dc.subject | PREDIMAR | en |
dc.title | Proteomics and recurrence of atrial fibrillation: a pilot study nested in the PREDIMAR trial | en |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 86d1b76e-4790-40b1-a3ec-72331c5c6199 | |
relation.isAuthorOfPublication | abacfd17-2b93-4d99-bae2-52053d57401e | |
relation.isAuthorOfPublication.latestForDiscovery | 86d1b76e-4790-40b1-a3ec-72331c5c6199 |
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