Proteomics and recurrence of atrial fibrillation: a pilot study nested in the PREDIMAR trial

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dc.contributor.authorRazquin, Cristina
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorBarrio-López, María Teresa
dc.contributor.authorLópez, Begoña
dc.contributor.authorRavassa, Susana
dc.contributor.authorRamos, Pablo
dc.contributor.authorMacías-Ruiz, Rosa
dc.contributor.authorIbáñez Criado, Alicia
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorGoñi, Leticia
dc.contributor.authorCastellanos, Eduardo
dc.contributor.authorIbáñez Criado, José Luis
dc.contributor.authorTercedor, Luis
dc.contributor.authorGarcía-Bolao, Ignacio
dc.contributor.authorMartínez González, Miguel Ángel
dc.contributor.authorAlmendral, Jesús
dc.contributor.authorRuiz Canela, Miguel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2025-06-30T15:41:39Z
dc.date.available2025-06-30T15:41:39Z
dc.date.issued2025-01-24
dc.date.updated2025-06-30T15:22:29Z
dc.description.abstractIntroduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia worldwide. Although catheter ablation is the most efficacious therapy, relapses occur frequently (30%) in the first year after ablation. Novel biomarkers of recurrence are needed for a better prediction of recurrence and management of AF. In this pilot study, we aimed to analyze the baseline proteome of subjects included in a case-control study to find differential proteins associated with AF recurrence. Methods: Baseline serum proteomics (354 proteins) data from 16 cases (recurrent AF) and 17 controls (non-recurrent) were obtained using MS/MS analysis. A false discovery rate was performed using a nonlinear fitting method for the selection of proteins. Logistic regression models were used to further analyze the association between differentially expressed proteins and AF recurrence. Results: Ten proteins were differentially represented in cases vs. controls. Two were upregulated in the cases compared to the controls: keratin type I cytoskeletal 17 (Fold-change [FC] = 2.14; p = 0.017) and endoplasmic bifunctional protein (FC = 1.65; p = 0.032). Eight were downregulated in the cases compared to the controls: C4bpA (FC = 0.64; p = 0.006), coagulation factor XI (FC = 0.83; p = 0.011), CLIC1 (FC = 0.62; p = 0.017), haptoglobin (FC = 0.37; p = 0.021), Ig alpha-2 chain C region (FC = 0.49; p = 0.022), C4bpB (FC = 0.73; p = 0.028), N-acetylglucosamine-1- phosphotransferase subunit gamma (FC = 0.61; p = 0.033), and platelet glycoprotein Ib alpha chain (FC = 0.84; p = 0.038). Conclusion: This pilot study identifies ten differentially expressed serum proteins associated with AF recurrence, offering potential biomarkers for improved prediction and management.en
dc.description.sponsorshipThis study was supported by the Spanish Government Official Agency for funding biomedical research - Instituto de Salud Carlos III (ISCIII) - with competitive grants through the Fondo de Investigación Sanitaria y Fondo Europeo de Desarrollo Regional (PI17/00718, PI17/00748, PI17/01870) and ProteoRed; the Regional Government of Navarra (46/2016); and the Spanish Society of Cardiology (FEC/2016).
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dc.format.mimetypeapplication/zip
dc.identifier.citationRazquin, C., Fernández-Irigoyen, J., Barrio-López, M. T., López, B., Ravassa, S., Ramos, P., Macías-Ruiz, R., Ibañez Criado, A., Santamaría, E., Goni, L., Castellanos, E., Ibáñez Criado, J. L., Tercedor, L., García-Bolao, I., Martínez-González, M. A., Almendral, J., Ruiz-Canela, M. (2025) Proteomics and recurrence of atrial fibrillation: a pilot study nested in the PREDIMAR trial. Lifestyle Genomics, 18(1), 52-58. https://doi.org/10.1159/000543639.
dc.identifier.doi10.1159/000543639
dc.identifier.issn2504-3161
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54349
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofLifestyle Genomics 2025, 18(1), 52-58
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F00718/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F00748/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01870/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra///
dc.relation.publisherversionhttps://doi.org/10.1159/000543639
dc.rights© 2025 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons AttributionNonCommercial 4.0 International License (CC BY-NC), usage and distributionfor commercial purposes requires written permission.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectProteomicsen
dc.subjectAtrial fibrillationen
dc.subjectRecurrenceen
dc.subjectPREDIMARen
dc.titleProteomics and recurrence of atrial fibrillation: a pilot study nested in the PREDIMAR trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication86d1b76e-4790-40b1-a3ec-72331c5c6199
relation.isAuthorOfPublicationabacfd17-2b93-4d99-bae2-52053d57401e
relation.isAuthorOfPublication.latestForDiscovery86d1b76e-4790-40b1-a3ec-72331c5c6199

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