Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia

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dc.contributor.authorVázquez Urio, Iria
dc.contributor.authorMaicas, Miren
dc.contributor.authorMarcotegui, Nerea
dc.contributor.authorConchillo, Ana
dc.contributor.authorGuruceaga, Elizabeth
dc.contributor.authorRomán-Gómez, José
dc.contributor.authorCalasanz, María José
dc.contributor.authorAgirre, Xabier
dc.contributor.authorPrósper, Felipe
dc.contributor.authorOdero, María D.
dc.contributor.departmentCienciases_ES
dc.contributor.departmentZientziakeu
dc.date.accessioned2025-01-14T13:05:50Z
dc.date.available2025-01-14T13:05:50Z
dc.date.issued2010-01-07
dc.date.updated2025-01-14T12:56:46Z
dc.descriptionAcceso cerrado a este documento. No se encuentra disponible para la consulta pública. Depositado en Academica-e para cumplir con los requisitos de evaluación y acreditación académica del autor/a (sexenios, acreditaciones, etc.).
dc.description.abstractWe read with great interest the work published by Dickstein et al. (1) showing that induced EVI1 expression in a murine model silences miR-124 expression by DNA methylation. The EVI1 gene codes for a transcription factor implicated in the development and progression of high-risk acute myeloid leukemia (AML) (2, 3). We quantify the expression of 250 microRNAs (miRNAs; TaqManHuman miRNA assay set) in 15 myeloid cell lines. Statistical analysis comparing cell lines with and without EVI1 protein identified miRNAs differentially expressed (B > 0)en
dc.description.sponsorshipThis work was supported by Ministerio Ciencia Innovación (PI081687), Instituto de Salud Carlos III del Ministerio de Ciencia e Innovación-Red Temática de Investigación Cooperativa en Cáncer (RD06/0020/0078-RD06/0020/0111), and Union temporal de empresas (UTE) proyecto Centro de Investigación Médica Aplicada (CIMA). Publicado 2010-10-07
dc.format.mimetypeapplication/pdfen
dc.identifier.citationVázquez, I., Maicas, M., Marcotegui, N., Conchillo, A., Guruceaga, E., Roman-Gomez, J., Calasanz, M. J., Agirre, X., Prosper, F., Odero, M. D. (2010). Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 107(44), 167-168. https://doi.org/10.1073/pnas.1011540107.
dc.identifier.doi10.1073/pnas.1011540107
dc.identifier.issn0027-8424
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52918
dc.language.isoeng
dc.publisherNational Academy of Sciences
dc.relation.ispartofProceedings of the National Academy of Sciences (PNAS) (2010), vol. 107, núm. 44
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PI081687/
dc.relation.publisherversionhttps://doi.org/10.1073/pnas.1011540107
dc.rights© 2010 PNAS
dc.rights.accessRightsinfo:eu-repo/semantics/closedAccess
dc.subjectEVI1 Overexpressionen
dc.subjecthsa-miR-124 Silencingen
dc.subjectDNA Methylationen
dc.titleSilencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemiaen
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
relation.isAuthorOfPublication3762d67a-d18f-4f29-8eee-8b4c20793cd8
relation.isAuthorOfPublication.latestForDiscovery3762d67a-d18f-4f29-8eee-8b4c20793cd8

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