Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis
| dc.contributor.author | Cuesta, Manuel J. | |
| dc.contributor.author | García de Jalón, Elena | |
| dc.contributor.author | Campos, María S. | |
| dc.contributor.author | Ibáñez, Berta | |
| dc.contributor.author | Sánchez Torres, Ana María | |
| dc.contributor.author | Peralta Martín, Víctor | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.contributor.funder | Gobierno de Navarra / Nafarroako Gobernua | es |
| dc.date.accessioned | 2024-01-29T10:27:05Z | |
| dc.date.available | 2024-01-29T10:27:05Z | |
| dc.date.issued | 2012 | |
| dc.date.updated | 2024-01-29T09:31:52Z | |
| dc.description.abstract | Background: Duration of untreated psychosis (DUP) has been significantly associated with poor clinical and social outcomes in First Episode Psychosis (FEP) patients, but an association with cognitive outcomes has not been clearly established. Method: Seventy-seven consecutively admitted, drug-naïve patients with FEP were assessed at baseline and at 1 month and 6 months. Underlying dimensions of DUP (general prodrome and positive, negative and disorganisation symptoms) were assessed using the Symptom Onset in Schizophrenia (SOS) inventory (Perkins et al., 2000). To assess the effect of DUP on the neuropsychological status of the patients, a linear mixed-effect model was fitted to each neuropsychological dimension. These models included a dichotomised version of DUP (short versus long duration) as a fixed effect, several adjusting variables to account for patient differences, and a random effect to incorporate the longitudinal structure of the data. Results: Patients with a short duration of untreated negative symptoms (DUNS) or a short duration of untreated positive symptoms (DUPS) outperformed patients with a long duration of untreated symptoms on memory tasks and a pre-attentional visual task but not on measures of verbal fluency, attention, reaction time, visual processing and executive functions. Conclusions: This study provides additional support for an early intervention to shorten DUP to facilitate a better outcome in memory and attentional domains of FEP patients. | en |
| dc.description.sponsorship | This work was supported by the Navarra government (grants 946/2005 and 55/2007), the ‘Fondo de Investigaciones Sanitarias’ from the Spanish Ministry of Health (grant PI081026) and the Spanish Ministry of Science and Innovation (grant SAF2008-05674-C03-02). | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Cuesta, M. J., García de Jalón, E., Campos, M. S., Ibáñez, B., Sánchez-Torres, A. M., Peralta, V. (2012) Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis. Schizophrenia Research, 141(2-3), 222-227. https://doi.org/10.1016/j.schres.2012.08.019. | en |
| dc.identifier.doi | 10.1016/j.schres.2012.08.019 | |
| dc.identifier.issn | 0920-9964 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/47216 | |
| dc.language.iso | eng | en |
| dc.publisher | Elsevier | en |
| dc.relation.ispartof | Schizophrenia Research 141 (2012) 222-227 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//SAF2008-05674-C03-02/ES/ | |
| dc.relation.publisherversion | https://doi.org/10.1016/j.schres.2012.08.019 | |
| dc.rights | © 2012 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0. | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Duration of untreated psychosis (DUP) | en |
| dc.subject | First episode psychosis | en |
| dc.subject | Longitudinal study | en |
| dc.subject | Cognition | en |
| dc.title | Duration of untreated negative and positive symptoms of psychosis and cognitive impairment in first episode psychosis | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 6cfdb372-fb89-4760-b1b8-404b0f0ae941 | |
| relation.isAuthorOfPublication.latestForDiscovery | 6cfdb372-fb89-4760-b1b8-404b0f0ae941 |