Biological sex as a tailoring variable for exercise prescription in hospitalized older adults

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dc.contributor.authorLópez Sáez de Asteasu, Mikel
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorLusa Cadore, Eduardo
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.departmentEstadística, Informática y Matemáticases_ES
dc.contributor.departmentEstatistika, Informatika eta Matematikaeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua, 2186/2014
dc.date.accessioned2025-01-23T16:53:59Z
dc.date.available2025-01-23T16:53:59Z
dc.date.issued2024-09-27
dc.date.updated2025-01-23T15:58:49Z
dc.description.abstractBackground. Sex-based differences in the clinical presentation and outcomes are well-established in patients hospitalized for geriatric syndromes. We aimed to investigate sex differences in response to in-hospital exercise on function, strength, cognition, and quality of life in acute care admissions. Methods. 570 patients (mean age 87 years, 298 females [52.3%]) admitted to acute care for elderly units were randomized to multicomponent exercise emphasizing progressive resistance training or usual care. Functional assessments included Short Physical Performance Battery (SPPB), grip strength, Mini-Mental State Examination (MMSE), and health-related quality of life (EQ-VAS). Results. Exercising females showed more significant SPPB improvements than males (between-group difference 1.48 points, p = 0.027), exceeding the minimal clinically significant difference. While female participants significantly increased handgrip strength and male patients improved cognition after in-hospital exercise compared to the control group (all p < 0.001), no sex differences occurred. Conclusions. Females demonstrate more excellent physical function improvements compared to male older patients. Findings highlight the importance of tailored exercise incorporating patient factors like biological sex in geriatric medicine. Trial registration. NCT04600453en
dc.description.sponsorshipThis study was funded by a Gobierno de Navarra project Resolución grant 2186/2014 and acknowledged with the “Beca Ortiz de Landazuri” for the best research clinical project in 2014. This study was also funded by a research grant PI17/01814 of the Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER). N.M-V received funding from the “la Caixa” Foundation (ID100010434) under agreement LCF/PR/PR15/51100006.
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/msworden
dc.identifier.citationSáez de Asteasu, M. L., Martínez-Velilla, N., Ramírez-Vélez, R., Zambom-Ferraresi, F., Galbete, A., Cadore, E. L., Izquierdo, M. (2024) Biological sex as a tailoring variable for exercise prescription in hospitalized older adults. The Journal of nutrition, health and aging, 28(11), 1-7. https://doi.org/10.1016/j.jnha.2024.100377.
dc.identifier.doi10.1016/j.jnha.2024.100377
dc.identifier.issn1279-7707
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53072
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofThe Journal of nutrition, health and aging 28(11), 2024, 100377, 1-7
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01814/ES/
dc.relation.publisherversionhttps://doi.org/10.1016/j.jnha.2024.100377
dc.rights© 2024 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher. This is an open access article under the CC BY-NC-ND license.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSex-based differencesen
dc.subjectGeriatric syndromesen
dc.subjectIn-hospital exerciseen
dc.subjectFunctional outcomesen
dc.titleBiological sex as a tailoring variable for exercise prescription in hospitalized older adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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