Publication:
Body composition and resting energy expenditure in a group of children with achondroplasia

Date

2024

Director

Publisher

Elsevier
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión publicada / Argitaratu den bertsioa

Project identifier

Abstract

Background: Persons with achondroplasia develop early obesity, which is a comorbidity associated with other complications. Currently, there are no validated specific predictive equations to estimate resting energy expenditure in achondroplasia. Methods: We analyzed the influence of body composition on this parameter and determined whether predictive models used for children with standard height are adjusted to achondroplasia. In this cross-sectional study, we measured anthropometric parameters in children with achondroplasia. Fat mass was obtained using the Slaughter skinfold-thickness equation and resting energy expenditure was determined with a Fitmate-Cosmed calorimeter and with predictive models validated for children with average height (Schofield, Institute of Medicine, and Tverskaya). Results: All of the equations yielded a lower mean value than resting energy expenditure with indirect calorimetry (1256±200 kcal/day [mean±SD]) but the closest was the Tverskaya equation (1017 ± 64 kcal/day), although the difference remained statistically significant. We conclude that weight and height have the greatest influence on resting energy expenditure. Conclusion: We recommend studying the relationship between body composition and energy expenditure in achondroplasia in more depth. In the absence of valid predictive models suitable for clinical use to estimate body composition and resting energy expenditure in achondroplasia, it is recommended to use the gold standard methods by taking into account certain anthropometric parameters.

Description

Keywords

Achondroplasia, Resting energy expenditure, Obesity, Indirect calorimetry, Body composition

Department

Ciencias de la Salud / Osasun Zientziak / Estadística, Informática y Matemáticas / Estatistika, Informatika eta Matematika / Institute for Advanced Materials and Mathematics - INAMAT2

Faculty/School

Degree

Doctorate program

item.page.cita

Garde-Etayo, L., Trandafir, P. C., Saint-Laurent, C., Ugarte, M. D., & Serrano, A. M. I. (2024). Body composition and resting energy expenditure in a group of children with achondroplasia. Archives de Pédiatrie, 31(2), 129-135. https://doi.org/10.1016/j.arcped.2023.10.005

item.page.rights

© 2023 The Authors. This is an open access article under the CC BY-NC-ND license.

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