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Individual trajectories of cognitive performance in first episode psychosis: a 2-year follow-up study

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dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorLorente Omeñaca, Ruth
dc.contributor.authorCabrera, Bibiana
dc.contributor.authorLobo, Antonio
dc.contributor.authorGonzález Pinto, Ana
dc.contributor.authorMerchán-Naranjo, Jessica
dc.contributor.authorCorripio, Iluminada
dc.contributor.authorVieta, Eduard
dc.contributor.authorSerna, Elena de la
dc.contributor.authorButjosa, Anna
dc.contributor.authorContreras, Fernando
dc.contributor.authorSarró, Salvador
dc.contributor.authorMezquida, Gisela
dc.contributor.authorRibeiro Fernández, María
dc.contributor.authorBernardo, Miguel
dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-01-22T16:43:41Z
dc.date.available2024-01-22T16:43:41Z
dc.date.issued2018
dc.date.updated2024-01-22T15:45:00Z
dc.description.abstractIndividual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in the case of frst episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition over 2 years of a sample of 159 FEP patients was reliable and clinically signifcant, using the reliable change index (RCI) and clinically signifcant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures. We analysed the course of cognitive measures over time, using analysis of variance, and the individual trajectories in the cognitive measures with the regression-based RCI (RCISRB) and the CSC. The RCISRB showed that between 5.4 and 31.2% of the patients showed deterioration patterns, and between 0.6 and 8.8% showed improvement patterns in these tests over time. Patients showing better cognitive profles according to RCISRB (worsening in zero to two cognitive measures) showed better premorbid, clinical and functional profles than patients showing deterioration patterns in more than three tests. When combining RCISRB and CSC values, we found that less than 10% of patients showed improvement or deterioration patterns in executive function and attention measures. These results support the view that cognitive impairments are stable over the frst 2 years of illness, but also that the analysis of individual trajectories could help to identify a subgroup of patients with particular phenotypes, who may require specifc interventions.en
dc.description.sponsorshipThis work was supported by the Carlos III Health Institute (European Regional Development Funds-ERDF) of the Spanish Ministry of Economic Afairs and Competitiveness (08/1026, 11/02831, 14/01621) and the Health Department of the Government of Navarra (87/2014).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSánchez-Torres, A. M., Moreno-Izco, L., Lorente-Omeñaca, R., Cabrera, B., Lobo, A., González-Pinto, A. M., Merchán-Naranjo, J., Corripio, I., Vieta, E., de la Serna, E., Butjosa, A., Contreras, F., Sarró, S., Mezquida, G., Ribeiro, M., Bernardo, M., Cuesta, M. J., PEPs group (2018) Individual trajectories of cognitive performance in first episode psychosis: A 2-year follow-up study. European Archives of Psychiatry and Clinical Neuroscience, 268(7), 699-711. https://doi.org/10.1007/s00406-017-0857-z.en
dc.identifier.doi10.1007/s00406-017-0857-z
dc.identifier.issn0940-1334
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/47129
dc.language.isoengen
dc.publisherSpringeren
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience (2018) 268, 699–711en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//08%2F1026/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PI11%2F02831/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01621/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//87%2F2014en
dc.relation.publisherversionhttps://doi.org/10.1007/s00406-017-0857-z
dc.rights© Springer-Verlag GmbH Germany, part of Springer Nature 2017.en
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.subjectFirst episode psychosisen
dc.subjectLongitudinalen
dc.subjectCognitionen
dc.subjectReliable change indexen
dc.subjectSchizophreniaen
dc.subjectClinically signifcant changeen
dc.titleIndividual trajectories of cognitive performance in first episode psychosis: a 2-year follow-up studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión aceptada / Onetsi den bertsioaes
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublicationc60095c1-5436-4633-9b1c-f7d8a73c0e32
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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