Circulating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck cancer

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dc.contributor.authorArrazubi, Virginia
dc.contributor.authorGoñi Irigoyen, Saioa
dc.contributor.authorGonzález Borja, Iranzu
dc.contributor.authorHernández García, Irene
dc.contributor.authorArasanz Esteban, Hugo
dc.contributor.authorPérez Sanz, Jairo
dc.contributor.authorBocanegra Gondán, Ana Isabel
dc.contributor.authorKochan, Grazyna
dc.contributor.authorEscors Murugarren, David
dc.contributor.authorRuiz de Azúa, Yerani
dc.contributor.authorElizalde, Jesús María
dc.contributor.authorViúdez, Antonio
dc.contributor.authorVera García, Ruth
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2024-04-29T13:46:27Z
dc.date.issued2023
dc.date.updated2024-04-29T12:48:28Z
dc.description.abstractBackground: Identification of predictive biomarkers to Immune checkpoint inhibitors (ICIs) in head and neck cancer (HNSCC) is an unmet need. Methods: This was a prospective observational study including 25 patients with HNSCC treated with immunotherapy or chemotherapy after a prior platinum-based regimen. Low density neutrophils (LDNs) and serum markers were analyzed. Results: In the immunotherapy cohort, patients with high LDN levels had a shorter progression free survival (PFS) (1.8 months vs. 10.9 months; *p = 0.034). Also, progressors showed higher percentage of LDNs compared to non-progressors although significance was not reached (mean 20.68% vs. 4.095%, p = 0.0875). These findings were not replicated in patients treated with chemotherapy. High levels of interleukin-7 (IL7) were correlated with a significantly longer overall survival (OS) (13.47 months 3.51 vs. months, *p = 0.013). Conclusions: High baseline circulating LDNs and low IL7 could identify a subset of patients intrinsically refractory to ICIs as monotherapy in HNSCC.en
dc.description.sponsorshipLa Caixa Foundation; Department ofEconomic Development, Government of Navarre; Spanish Society of Medical Oncology (SEOM)en
dc.embargo.inicio2024-04-29
dc.embargo.lift2024-12-01
dc.embargo.terms2024-12-01
dc.format.mimetypeapplication/pdfen
dc.identifier.citationArrazubi, V., Goñi, S., González-Borja, I., Hernandez-Garcia, I., Arasanz, H., Pérez-Sanz, J., Bocanegra, A. I., Kochan, G., Escors, D., Ruiz de Azúa, Y., Elizalde, J. M., Viúdez, A., Vera, R. (2023) Circulating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck cancer. Head & Neck: Journal for the Sciences and Specialities of the Head and Neck, 45(12), 3075-3085. https://doi.org/10.1002/hed.27536.en
dc.identifier.doi10.1002/hed.27536
dc.identifier.issn1043-3074
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48042
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofHead & Neck: Journal for the Sciences and Specialities of the Head and Neck, 2023, 45(12), 3075–3085en
dc.relation.publisherversionhttps://doi.org/10.1002/hed.27536
dc.rights© 2023 Wiley Periodicals LLC.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectBiomarkeren
dc.subjectHead and neck cancer (HNC)en
dc.subjectImmunotherapyen
dc.subjectLow density neutrophils (LDN)en
dc.subjectPredictiveen
dc.titleCirculating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck canceren
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication7945ddd5-cf8b-4927-bd7a-4ade2fb61f11
relation.isAuthorOfPublication.latestForDiscovery7945ddd5-cf8b-4927-bd7a-4ade2fb61f11

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