Circulating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck cancer
dc.contributor.author | Arrazubi, Virginia | |
dc.contributor.author | Goñi Irigoyen, Saioa | |
dc.contributor.author | González Borja, Iranzu | |
dc.contributor.author | Hernández García, Irene | |
dc.contributor.author | Arasanz Esteban, Hugo | |
dc.contributor.author | Pérez Sanz, Jairo | |
dc.contributor.author | Bocanegra Gondán, Ana Isabel | |
dc.contributor.author | Kochan, Grazyna | |
dc.contributor.author | Escors Murugarren, David | |
dc.contributor.author | Ruiz de Azúa, Yerani | |
dc.contributor.author | Elizalde, Jesús María | |
dc.contributor.author | Viúdez, Antonio | |
dc.contributor.author | Vera García, Ruth | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.date.accessioned | 2024-04-29T13:46:27Z | |
dc.date.issued | 2023 | |
dc.date.updated | 2024-04-29T12:48:28Z | |
dc.description.abstract | Background: Identification of predictive biomarkers to Immune checkpoint inhibitors (ICIs) in head and neck cancer (HNSCC) is an unmet need. Methods: This was a prospective observational study including 25 patients with HNSCC treated with immunotherapy or chemotherapy after a prior platinum-based regimen. Low density neutrophils (LDNs) and serum markers were analyzed. Results: In the immunotherapy cohort, patients with high LDN levels had a shorter progression free survival (PFS) (1.8 months vs. 10.9 months; *p = 0.034). Also, progressors showed higher percentage of LDNs compared to non-progressors although significance was not reached (mean 20.68% vs. 4.095%, p = 0.0875). These findings were not replicated in patients treated with chemotherapy. High levels of interleukin-7 (IL7) were correlated with a significantly longer overall survival (OS) (13.47 months 3.51 vs. months, *p = 0.013). Conclusions: High baseline circulating LDNs and low IL7 could identify a subset of patients intrinsically refractory to ICIs as monotherapy in HNSCC. | en |
dc.description.sponsorship | La Caixa Foundation; Department ofEconomic Development, Government of Navarre; Spanish Society of Medical Oncology (SEOM) | en |
dc.embargo.inicio | 2024-04-29 | |
dc.embargo.lift | 2024-12-01 | |
dc.embargo.terms | 2024-12-01 | |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Arrazubi, V., Goñi, S., González-Borja, I., Hernandez-Garcia, I., Arasanz, H., Pérez-Sanz, J., Bocanegra, A. I., Kochan, G., Escors, D., Ruiz de Azúa, Y., Elizalde, J. M., Viúdez, A., Vera, R. (2023) Circulating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck cancer. Head & Neck: Journal for the Sciences and Specialities of the Head and Neck, 45(12), 3075-3085. https://doi.org/10.1002/hed.27536. | en |
dc.identifier.doi | 10.1002/hed.27536 | |
dc.identifier.issn | 1043-3074 | |
dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/48042 | |
dc.language.iso | eng | en |
dc.publisher | Wiley | en |
dc.relation.ispartof | Head & Neck: Journal for the Sciences and Specialities of the Head and Neck, 2023, 45(12), 3075–3085 | en |
dc.relation.publisherversion | https://doi.org/10.1002/hed.27536 | |
dc.rights | © 2023 Wiley Periodicals LLC. | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
dc.subject | Biomarker | en |
dc.subject | Head and neck cancer (HNC) | en |
dc.subject | Immunotherapy | en |
dc.subject | Low density neutrophils (LDN) | en |
dc.subject | Predictive | en |
dc.title | Circulating low density neutrophils are associated with resistance to anti-PD1 immunotherapy in squamous head and neck cancer | en |
dc.type | info:eu-repo/semantics/article | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 7945ddd5-cf8b-4927-bd7a-4ade2fb61f11 | |
relation.isAuthorOfPublication.latestForDiscovery | 7945ddd5-cf8b-4927-bd7a-4ade2fb61f11 |