Publication: Being born in winter-spring and at around the time of an influenza pandemic are risk factors for the development of schizophrenia: the apna study in Navarre, Spain
| dc.contributor.author | Álvarez-Mon, Miguel Ángel | |
| dc.contributor.author | Guillén Aguinaga, Sara | |
| dc.contributor.author | Pereira-Sánchez, Víctor | |
| dc.contributor.author | Onambele, Luc | |
| dc.contributor.author | Al-Rahamneh, Moad J. | |
| dc.contributor.author | Brugos Larumbe, Antonio | |
| dc.contributor.author | Guillén Grima, Francisco | |
| dc.contributor.author | Ortuño, Felipe | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.date.accessioned | 2022-01-11T09:29:23Z | |
| dc.date.available | 2022-01-11T09:29:23Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Background: we analyzed the relationship between the prevalence of schizophrenia and the season of birth and gestation during a period of an influenza pandemic. Methods: cross-sectional analysis of a prospective population-based cohort of 470,942 adults. We fitted multivariant logistic regression models to determine whether the season of birth and birth in an influenza-pandemic year (1957, 1968, 1977) was associated with schizophrenia. Results: 2077 subjects had been diagnosed with schizophrenia. Logistic regression identified a significantly greater prevalence of schizophrenia in men than in women (OR = 1.516, CI 95% = 1.388–1.665); in those born in the winter or spring than in those born in the summer or autumn (OR = 1.112, CI 95% = 1.020–1.212); and in those born in a period of an influenza pandemic (OR = 1.335, CI 95% = 1.199–1.486). The increase in risk was also significant when each influenza pandemic year was analyzed separately. However, neither month of birth nor season of birth, when each of the four were studied individually, were associated with a statistically significant increase in that risk. Conclusions: the winter–spring period and the influenza pandemics are independent risk factors for developing schizophrenia. This study contradicts many previous studies and thus revitalizes a locked debate in understanding the neurodevelopmental hypothesis of this disorder. | en |
| dc.description.sponsorship | This research was funded by grants from The Institute of Health Carlos III (ISCIII). | |
| dc.format.extent | 10 p. | |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | 10.3390/jcm10132859 | |
| dc.identifier.issn | 2077-0383 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/41690 | |
| dc.language.iso | eng | en |
| dc.publisher | MDPI | |
| dc.relation.ispartof | Journal of Clinical Medicine, 10 (13) | |
| dc.relation.publisherversion | http://doi.org/10.3390/jcm10132859 | |
| dc.rights | © 2021 by the authors. Creative Commons Attribution | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
| dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Influenza pandemic | en |
| dc.subject | Neurodevelopmental hypothesis | en |
| dc.subject | Schizophrenia | en |
| dc.subject | Season of birth | en |
| dc.title | Being born in winter-spring and at around the time of an influenza pandemic are risk factors for the development of schizophrenia: the apna study in Navarre, Spain | en |
| dc.type | info:eu-repo/semantics/article | en |
| dc.type | Artículo / Artikulua | es |
| dc.type.version | info:eu-repo/semantics/publishedVersion | en |
| dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
| dspace.entity.type | Publication | |
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| relation.isAuthorOfPublication.latestForDiscovery | 359f165a-4c28-44bf-b931-6e5243be44db |