A neuropsychological study on Leonhard's nosological system

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dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorGil Berrozpe, Gustavo José
dc.contributor.authorLorente Omeñaca, Ruth
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorSEGPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2025-08-11T16:54:45Z
dc.date.available2025-08-11T16:54:45Z
dc.date.issued2022-04-01
dc.date.updated2025-08-11T16:38:25Z
dc.description.abstractPhenotype validation of endogenous psychosis is a problem that remains to be solved. This study investigated the neuropsychological performance of endogenous psychosis subtypes according to Wernicke–Kleist–Leonhard’s classification system (WKL). The participants included consecutive admissions of patients with schizophrenia spectrum disorder or mood disorder with psychotic symptoms (N = 98) and healthy comparison subjects (N = 50). The patients were assessed by means of semi-structured interviews and diagnosed through the WKL system into three groups: a manic-depressive illness and cycloid psychosis group (MDC), unsystematic schizophrenia (USch) and systematic schizophrenia (SSch). All the participants completed a comprehensive neuropsychological battery. The three Leonhard’s psychosis subtypes showed a common neuropsychological profile with differences in the severity of impairment relative to healthy controls. MDC patients showed better performance on premorbid intelligence, verbal memory and global cognitive index than USch and SSch patients, and they showed better performance on processing speed, and working memory than SSch patients. USch patients outperformed SSch patients in verbal memory, working memory and global cognitive index. Neuropsychological performance showed a modest accuracy for classification into the WKL nosology. Our results suggest the existence of a common profile of cognitive impairment cutting across WKL subtypes of endogenous psychosis but with significant differences on a severity continuum. In addition, classification accuracy in the three WKL subtypes by means of neuropsychological performance was modest, ranging between 40 and 64% of correctly classified patients.en
dc.description.sponsorshipThis work was supported by the Government of Navarra (grants 17/31, 18/41, 87/2014) and the Carlos III Health Institute (FEDER Funds) from the Spanish Ministry of Economy and Competitivity (14/01621 and 16/02148).
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/msword
dc.identifier.citationCuesta, M. J., Sánchez-Torres, A. M., Gil-Berrozpe, G., Lorente-Omeñaca, R., Moreno-Izco, L., Peralta, V., SegPEPs Group (2022) A neuropsychological study on Leonhard's nosological system. European Archives of Psychiatry and Clinical Neuroscience, 272(3), 427-436. https://doi.org/10.1007/s00406-021-01298-0.
dc.identifier.doi10.1007/s00406-021-01298-0
dc.identifier.issn0940-1334
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54652
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience 272, 427-436, (2022)
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra///
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra///
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra///
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI14%2F01621/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F02148/ES/
dc.relation.publisherversionhttps://doi.org/10.1007/s00406-021-01298-0
dc.rights© Springer-Verlag GmbH Germany, part of Springer Nature 2021.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectSchizophreniaen
dc.subjectWernickeen
dc.subjectKleisten
dc.subjectLeonharden
dc.subjectClassificationen
dc.subjectCycloid psychosisen
dc.subjectCognitionen
dc.subjectManic-depressive illnessen
dc.titleA neuropsychological study on Leonhard's nosological systemen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication377cf360-8d08-46f8-b10d-0785571f24c4
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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