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Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

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dc.contributor.authorMartín Peláez, Sandra
dc.contributor.authorSerra-Majem, Lluis
dc.contributor.authorCano Ibáñez, Noemí
dc.contributor.authorMartínez González, Miguel Ángel
dc.contributor.authorSalas-Salvadó, Jordi
dc.contributor.authorCorella, Dolores
dc.contributor.authorLassale, Camille
dc.contributor.authorMartínez, Jose Alfredo
dc.contributor.authorAlonso Gómez, Ángel M.
dc.contributor.authorWärnberg, Julia
dc.contributor.authorVioque, Jesús
dc.contributor.authorRomaguera, Dora
dc.contributor.authorLópez Miranda, José
dc.contributor.authorEstruch, Ramón
dc.contributor.authorTinahones, Francisco J.
dc.contributor.authorLapetra, José
dc.contributor.authorFernández-Aranda, Fernando
dc.contributor.authorBueno Cavanillas, Aurora
dc.contributor.authorTur, Josep A.
dc.contributor.authorMartín, Vicente
dc.contributor.authorPintó, Xavier
dc.contributor.authorDelgado Rodríguez, Miguel
dc.contributor.authorMatía, Pilar
dc.contributor.authorVidal, Josep
dc.contributor.authorVázquez, Clotilde
dc.contributor.authorDaimiel, Lidia
dc.contributor.authorRos, Emilio
dc.contributor.authorToledo, Estefanía
dc.contributor.authorNishi, Stephanie K.
dc.contributor.authorSorli, Jose V.
dc.contributor.authorMalcampo, Mireia
dc.contributor.authorZulet, María Ángeles
dc.contributor.authorMoreno Rodríguez, Anaí
dc.contributor.authorCueto Galán, Raquel
dc.contributor.authorVivancos Aparicio, Diego
dc.contributor.authorColom, Antoni
dc.contributor.authorGarcía-Rios, Antonio
dc.contributor.authorCasas, Rosa
dc.contributor.authorBernal López, M. Rosa
dc.contributor.authorSantos Lozano, José Manuel
dc.contributor.authorVázquez, Zenaida
dc.contributor.authorGómez-Martínez, Carlos
dc.contributor.authorOrtega Azorín, Carolina
dc.contributor.authorVal, José Luis del
dc.contributor.authorAbete, Itziar
dc.contributor.authorGoikoetxea Bahon, Amaia
dc.contributor.authorPascual, Elena
dc.contributor.authorBecerra-Tomás, Nerea
dc.contributor.authorChillarón, Juan J.
dc.contributor.authorSánchez Villegas, María Almudena
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2022-09-05T08:28:09Z
dc.date.available2022-09-05T08:28:09Z
dc.date.issued2022
dc.date.updated2022-09-05T08:11:59Z
dc.description.abstractBackground Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.en
dc.description.sponsorshipThe PREDIMED-Plus trial was supported by the European Research Council through a grant to MAM (Advanced Research Grant 2013-2018; 340918). The project was also supported by the official funding agency for biomedical research of the Spanish Government (ISCIII) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (four coordinated FIS projects), who awarded grants to JS and JV (PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732 and PI17/00926). The International Nut&Dried Fruit Council-FESNAD also provided funding through a grant to MAM (201302), and Recercaixa also awarded a grant to JS (2013ACUP00194). The Department of Health, Generalitat de Cataluña by the calls 'Acció instrumental de programes de recerca orientats en lámbit de la recercaila innovació en salut' and 'Pla estrategic de recerca i innovació en salut (PERIS),' also awarded a grant to FF (SLT006/17/00246). This research was also partially funded by: Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); Generalitat Valenciana (PROMETEO/2017/017); SEMERGEN, CIBEROBN, FEDER and ISCIII (CB06/03); EU-H2020 Grants (Eat2beNICE/h2020-sfs-2016-2, ref.728018; PRIME/h2020-SC1-BHC-2018-2020, ref: 847879).en
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dc.identifier.citationMartín-Peláez, S.; Serra-Majem, L.; Cano-Ibáñez, N.; Martínez-González, M. Á.; Salas-Salvadó, J.; Corella, D.; Lassale, C.; Martínez, J. A.; Alonso-Gómez, Á. M.; Wärnberg, J.; Vioque, J.; Romaguera, D.; López-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Fernández-Aranda, F.; Bueno-Cavanillas, A.; Tur, J. A.; Martín, V.; Pintó, X.; Delgado-Rodríguez, M.; Matía, P.; Vidal, J.; Vázquez, C.; Daimiel, L.; Ros, E.; Toledo, E.; Nishi, S. K.; Sorli, J. V.; Malcampo, M.; Zulet, M. Á.; Moreno-Rodríguez, A.; Cueto-Galán, R.; Vivancos-Aparicio, D.; Colom. A.; García-Ríos, A.; Casas, R.; Bernal-López, M. R.; Santos-Lozano, J. M.; Vázquez, Z.; Gómez-Martínez, C.; Ortega-Azorín, C.; del Val, J. L.; Abete, I.; Goikoetxea-Bahon, A.; Pascual, E.; Becerra-Tomás, N.; Chillarón, J. J.; Sánchez-Villegas, A.. (2022). Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. PloS one. 17,4 1-18 .en
dc.identifier.doi10.1371/journal.pone.0265079
dc.identifier.issn1932-6203
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/43953
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPLoS One 17en
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dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0265079
dc.rights© 2022 Martín-Peláez et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licenseen
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectCardio-vascular risk factorsen
dc.subjectPredimed-plusen
dc.subjectCardio-vascular diseaseen
dc.subjectDepressionen
dc.titleContribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
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relation.isAuthorOfPublication.latestForDiscoveryae8afd07-1f10-4da5-8582-93b90a18aa88

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