Multidimensional outcome of first-episode psychosis: a network analysis

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dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorGil Berrozpe, Gustavo José
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorGarcía de Jalón, Elena
dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorSEGPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2025-06-24T10:31:55Z
dc.date.available2025-06-24T10:31:55Z
dc.date.issued2025-02-06
dc.date.updated2025-06-24T10:12:32Z
dc.description.abstractBackground Few studies have examined the long-term outcomes of first-episode psychosis (FEP) among patients beyond symptomatic and functional remission. This study aimed to broaden the scope of outcome indicators by examining the relationships between 12 outcomes of FEP patients at 20.9 years after their initial diagnosis. Methods At follow-up, 220 out of 550 original patients underwent a new assessment. Twelve outcomes were assessed via semistructured interviews and complementary scales: symptom severity, functional impairment, personal recovery, social disadvantage, physical health, number of suicide attempts, number of episodes, current drug use, dose-years of antipsychotics (DYAps), cognitive impairment, motor abnormalities, and DSM-5 final diagnosis. The relationships between these outcome measures were investigated using Spearman's correlation analysis and exploratory factor analysis, while the specific connections between outcomes were ascertained using network analysis. Results The outcomes were significantly correlated; specifically, symptom severity, functioning, and personal recovery showed the strongest correlations. Exploratory factor analysis of the 12 outcomes revealed two factors, with 11 of the 12 outcomes loading on the first factor. Network analysis revealed that symptom severity, functioning, social disadvantage, diagnosis, cognitive impairment, DYAps, and number of episodes were the most interconnected outcomes. Conclusion Network analysis provided new insights into the heterogeneity between outcomes among patients with FEP. By considering outcomes beyond symptom severity, the rich net of interconnections elucidated herein can facilitate the development of interventions that target potentially modifiable outcomes and generalize their impact on the most interconnected outcomes.en
dc.description.sponsorshipFunding for the study came from the Gobierno de Navarra (grants 31/17 and 41/18), Ministerio de Economía, Industria y Competitividad de España (grants PI16/02148 and 19/01698), and Instituto de Salud Carlos III (ISCIII) (grant RD21/0009/0001),
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dc.format.mimetypeapplication/msword
dc.identifier.citationCuesta, M. J., Gil-Berrozpe, G. J., Sánchez-Torres, A. M., Moreno-Izco, L., García De Jalón, E., Peralta, V. (2025). Multidimensional outcome of first-episode psychosis: a network analysis. Psychological Medicine, 55, 1-13. https://doi.org/10.1017/S0033291724003465.
dc.identifier.doi10.1017/S0033291724003465
dc.identifier.issn0033-2917
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/54304
dc.language.isoeng
dc.publisherCambridge University Press
dc.relation.ispartofPsychological Medicine (2025), vol. 55, e29
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F02148/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F01698/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII//RD21%2F0009%2F0001/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//31%2F17/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//41%2F18/
dc.relation.publisherversionhttps://doi.org/10.1017/S0033291724003465
dc.rightsThe Author(s), 2025. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence, which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFirst-episode psychosisen
dc.subjectNetwork analysisen
dc.subjectOutcome measuresen
dc.subjectRecoveryen
dc.subjectSchizophreniaen
dc.titleMultidimensional outcome of first-episode psychosis: a network analysisen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication377cf360-8d08-46f8-b10d-0785571f24c4
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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