The association of adverse childhood experiences with long-term outcomes of psychosis: a 21-year prospective cohort study after a first episode of psychosis

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dc.contributor.authorPeralta Martín, Víctor
dc.contributor.authorGarcía de Jalón, Elena
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorPeralta, David
dc.contributor.authorJanda-Galán, Lucía
dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorSEGPEPs Group
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua
dc.date.accessioned2024-10-03T10:39:12Z
dc.date.issued2024
dc.date.updated2024-10-03T10:26:10Z
dc.description.abstractBackground Evidence suggests a possible relationship between exposure to childhood adversity (CA) and functional impairment in psychosis. However, the impact of CA on long-term outcomes of psychotic disorders remains poorly understood. Methods Two hundred and forty-three patients were assessed at their first episode of psychosis for CA and re-assessed after a mean of 21 years of follow-up for several outcome domains, including symptoms, functioning, quality of life, cognitive performance, neurological dysfunction, and comorbidity. The unique predictive ability of CA exposure for outcomes was examined using linear regression analysis controlling for relevant confounders, including socioeconomic status, family risk of schizophrenia, and obstetric complications. Results There were 54% of the patients with a documented history of CA at mild or higher levels. CA experiences were more prevalent and severe in schizophrenia than in other psychotic disorders (p < 0.001). Large to very large effect sizes were observed for CA predicting most role functioning variables and negative symptoms (¿R2 between 0.105 and 0.181). Moderate effect sizes were observed for positive symptoms, personal functioning, impaired social cognition, impaired immediate verbal learning, poor global cognition, internalized stigma, poor personal recovery, and drug abuse severity (¿R2 between 0.040 and 0.066). A dose¿response relationship was observed between levels of CA and severity of outcome domains. Conclusion Our results suggest a strong and widespread link between early adversity exposure and outcomes of psychotic disorders. Awareness of the serious long-term consequences of CA should encourage better identification of those at risk and the development of effective interventions.en
dc.description.sponsorshipThe study was funded by the Spanish Ministry of Economy, Industry and Competitiveness (grant PI16/02148 and 19/01698) and the Regional Government of Navarra (grant 31/17 and 41/18).
dc.embargo.inicio2024-10-03
dc.embargo.lift2024-11-30
dc.embargo.terms2024-11-30
dc.format.mimetypeapplication/pdfen
dc.identifier.citationPeralta, V., García de Jalón, E., Moreno-Izco, L., Peralta, D., Janda, L., Sánchez-Torres, A. M., Cuesta, M. J., Segpep Group (2024). The association of adverse childhood experiences with long-term outcomes of psychosis: A 21-year prospective cohort study after a first episode of psychosis. Psychological Medicine, 1-10. https://doi.org/10.1017/S0033291724001223.
dc.identifier.doi10.1017/S0033291724001223
dc.identifier.issn0033-2917
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/51957
dc.language.isoeng
dc.publisherCambridge University Press
dc.relation.ispartofPsychological Medicine (2024)
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F02148/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F01698/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//31%2F17/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//41%2F18/
dc.relation.publisherversionhttps://doi.org/10.1017/S0033291724001223
dc.rights© The Author(s), 2024.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectChildhood adversityen
dc.subjectFirst-episode psychosisen
dc.subjectLong-term follow-up outcomeen
dc.titleThe association of adverse childhood experiences with long-term outcomes of psychosis: a 21-year prospective cohort study after a first episode of psychosisen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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