Biofilm switch and immune response determinants at early stages of infection

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dc.contributor.authorValle Turrillas, Jaione
dc.contributor.authorSolano Goñi, Cristina
dc.contributor.authorGarcía Martínez, Begoña
dc.contributor.authorToledo Arana, Alejandro
dc.contributor.authorLasa Uzcudun, Íñigo
dc.contributor.departmentIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutuaes_ES
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua: IIQ14066.RI1es
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua: IIM13329.RI1es
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernua: 1312/2010es
dc.date.accessioned2016-11-04T15:28:56Z
dc.date.available2016-11-04T15:28:56Z
dc.date.issued2013
dc.description.abstractBiofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a sessile lifestyle and start producing a biofilm matrix. The initial steps of in vivo biofilm development are poorly characterized and difficult to assess experimentally. A great amount of in vitro evidence has shown that accumulation of high levels of cyclic dinucleotides (c-di-NMPs) is the most prevalent hallmark governing the initiation of biofilm development by bacteria. As mentioned above, recent studies also link detection of c-di-NMPs by host cells with the activation of a type I interferon immune response against bacterial infections. We discuss here c-di-NMP signaling and the host immune response in the context of the initial steps of in vivo biofilm development.en
dc.description.sponsorshipJ. Valle was supported by Spanish Ministry of Science and Innovation ‘Ramón y Cajal’ contract. Work in the Laboratory of Microbial Biofilms is funded by the Spanish Ministry of Economy and Competitiveness grants BIO2011-30503-C02-02, AGL2011-23954, and BFU2011-23222, as well as by ERA-NET Pathogenomics (PIM2010EPA-00606) and grants from the Departamento de Innovación (IIQ14066.RI1 and IIM13329.RI1) and Departamento de Salud (Resolución 1312/2010), Gobierno de Navarra.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1016/j.tim.2013.05.008
dc.identifier.issn0966-842X (Print)
dc.identifier.issn1878-4380 (Electronic)
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/22576
dc.language.isoengen
dc.publisherElsevier (Cell Press)en
dc.relation.ispartofTrends in Microbiology, August 2013, Vol. 21, No. 8en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//BIO2011-30503-C02-02/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/AGL2011-23954/
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/BFU2011-23222/
dc.relation.publisherversionhttps://dx.doi.org/10.1016/j.tim.2013.05.008
dc.rights© 2013 Elsevier Ltd. All rights reserved.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectBiofilmsen
dc.subjectChronic infectionsen
dc.subjectInnate immune responseen
dc.subjectc-di-GMPen
dc.subjectSTINGen
dc.subjectPAMPsen
dc.subjectType I interferonen
dc.subjectcGASen
dc.titleBiofilm switch and immune response determinants at early stages of infectionen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
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