Publication:
Biofilm switch and immune response determinants at early stages of infection

Date

2013

Director

Publisher

Elsevier (Cell Press)
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión aceptada / Onetsi den bertsioa

Project identifier

MICINN//BIO2011-30503-C02-02/ES/recolecta
ES/6PN/AGL2011-23954
ES/6PN/BFU2011-23222
Métricas Alternativas

Abstract

Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a sessile lifestyle and start producing a biofilm matrix. The initial steps of in vivo biofilm development are poorly characterized and difficult to assess experimentally. A great amount of in vitro evidence has shown that accumulation of high levels of cyclic dinucleotides (c-di-NMPs) is the most prevalent hallmark governing the initiation of biofilm development by bacteria. As mentioned above, recent studies also link detection of c-di-NMPs by host cells with the activation of a type I interferon immune response against bacterial infections. We discuss here c-di-NMP signaling and the host immune response in the context of the initial steps of in vivo biofilm development.

Description

Keywords

Biofilms, Chronic infections, Innate immune response, c-di-GMP, STING, PAMPs, Type I interferon, cGAS

Department

IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua

Faculty/School

Degree

Doctorate program

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