Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: a systematic review

Osés Recalde, Maddi; Margareto, Javier; Portillo, María P.; Aguilera, Concepción María; Labayen Goñi, Idoia

Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: a systematic review

dc.contributor.author	Osés Recalde, Maddi
dc.contributor.author	Margareto, Javier
dc.contributor.author	Portillo, María P.
dc.contributor.author	Aguilera, Concepción María
dc.contributor.author	Labayen Goñi, Idoia
dc.contributor.department	Institute on Innovation and Sustainable Development in Food Chain - ISFOOD	en
dc.date.accessioned	2020-05-19T06:57:55Z
dc.date.available	2020-05-19T06:57:55Z
dc.date.issued	2019
dc.description.abstract	Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142–3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.	en
dc.description.sponsorship	This research was funded by the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R) and by the European Regional Development Fund (ERDF), M.O. is supported by a grant from the Spanish Ministry of Economy and Competitiveness, grant number; BES-2017-080770 and the APC was funded by additional support from the University of Granada, UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme, and Excellence Actions Programe. C.M.A. and I.L.G. are part of the 'URG Plan propio de Investigación 2016' and the 'Excellence actions: Unit of Excellence on Exercise and Health (UCEES)', University of Granada.	en
dc.format.extent	13 p.
dc.format.mimetype	application/pdf	en
dc.identifier.doi	10.3390/nu11122890
dc.identifier.issn	2072-6643
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/36914
dc.language.iso	eng	en
dc.publisher	MDPI	en
dc.relation.ispartof	Nutrients, 2019, 11 (12), 2890	en
dc.relation.projectID	info:eu-repo/grantAgreement/ES/1PE/DEP2016-78377-R/
dc.relation.publisherversion	https://doi.org/10.3390/nu11122890
dc.rights	© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY)	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	MiRNAs	en
dc.subject	Childhood obesity	en
dc.subject	Biomarkers	en
dc.title	Circulating miRNAs as biomarkers of obesity and obesity-associated comorbidities in children and adolescents: a systematic review	en
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Publication
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