Subchronic use of rivastigmine increases procognitive flexibility across multimodal behavioral tasks in healthy male rats
| dc.contributor.author | Hormigo, Sebastian | |
| dc.contributor.author | Rodríguez Lorenzana, Alberto | |
| dc.contributor.author | Castro-Salazar, E. | |
| dc.contributor.author | Millian Morell, Lymarie | |
| dc.contributor.author | López, Dolores E. | |
| dc.contributor.department | Ciencias de la Salud | es_ES |
| dc.contributor.department | Osasun Zientziak | eu |
| dc.date.accessioned | 2024-02-06T17:18:10Z | |
| dc.date.available | 2024-02-06T17:18:10Z | |
| dc.date.issued | 2019 | |
| dc.date.updated | 2024-02-06T12:19:33Z | |
| dc.description.abstract | Rivastigmine (RVT) is a reversible inhibitor of cholinesterase approved worldwide for the treatment of cognitive dysfunctions, especially in Alzheimer's disease. Most previous pre-clinical studies have examined the effects of RVT treatment in a wide variety of pathological research models. Nonetheless, the effects of this drug on sensorimotor gating, memory, and learning tasks in healthy subjects remains unclear. In this study, we investigate the procognitive effects of RVT treatment in healthy rats through sensorimotor gating evaluations (measured as prepulse inhibition of the acoustic startle reflex), active avoidance learning, and spatial memory learning in a radial maze. There is an increase in the amplitude of the startle reflex in RVT-treated rats compared to the control groups, whereas the latency remained constant. Sensorimotor gating values were also incremented compared to those values from controls. In active avoidance, rats treated with RVT learned faster to successfully perform the task compared to controls, but afterwards all groups exhibited virtually identical results. During the sessions in the radial maze, RVT-treated rats committed fewer errors in both the working and reference memory compared to controls. All in all, our results support the hypothesis that RVT treatment may entail procognitive effects in healthy subjects. | en |
| dc.description.sponsorship | This study was supported in part by Spanish grants SAF2016-78898-C2-2R (MINECO) and by the University of Salamanca Research Support Grant for GIRs 2018. E. C.-S. was supported by a Master Research Scholarship from Ministerio de Educación Superior Ciencia y Tecnología de la República Dominicana (MESCyT). | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.citation | Hormigo, S., Rodriguez-Lorenzana, A., Castro-Salazar, E., Millian-Morell, L., López, D. E. (2019) Subchronic use of rivastigmine increases procognitive flexibility across multimodal behavioral tasks in healthy male rats. Behavioural Brain Research, 376, 1-9. https://doi.org/10.1016/j.bbr.2019.112077. | en |
| dc.identifier.doi | 10.1016/j.bbr.2019.112077 | |
| dc.identifier.issn | 0166-4328 | |
| dc.identifier.uri | https://academica-e.unavarra.es/handle/2454/47337 | |
| dc.language.iso | eng | en |
| dc.publisher | Elsevier | en |
| dc.relation.ispartof | Behavioural Brain Research 376 (2019) 11207 | en |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//SAF2016-78898-C2-2R/ | |
| dc.relation.publisherversion | https://doi.org/10.1016/j.bbr.2019.112077 | |
| dc.rights | © 2019 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 | en |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Acetylcholinesterase | en |
| dc.subject | Active avoidance | en |
| dc.subject | Prepulse inhibition | en |
| dc.subject | Radial maze | en |
| dc.subject | Sensorimotor gating | en |
| dc.subject | Startle reflex | en |
| dc.title | Subchronic use of rivastigmine increases procognitive flexibility across multimodal behavioral tasks in healthy male rats | en |
| dc.type | info:eu-repo/semantics/article | |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 5d4af467-7d54-453e-94d0-d39d7c76369a | |
| relation.isAuthorOfPublication.latestForDiscovery | 5d4af467-7d54-453e-94d0-d39d7c76369a |