No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial

Simple item page
dc.contributor.authorMartínez Téllez, Borja
dc.contributor.authorSánchez Delgado, Guillermo
dc.contributor.authorAcosta, Francisco M.
dc.contributor.authorAlcántara Alcántara, Juan Manuel
dc.contributor.authorAmaro Gahete, Francisco J.
dc.contributor.authorMartínez Ávila, Wendy D.
dc.contributor.authorMerchán Ramírez, Elisa
dc.contributor.authorMuñoz-Hernández, Victoria
dc.contributor.authorOsuna Prieto, Francisco J.
dc.contributor.authorJurado Fasoli, Lucas
dc.contributor.authorXu, Huiwen
dc.contributor.authorOrtiz Álvarez, Lourdes
dc.contributor.authorArias Téllez, María J.
dc.contributor.authorMéndez Gutiérrez, Andrea
dc.contributor.authorLabayen Goñi, Idoia
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorSchönke, Milena
dc.contributor.authorRensen, Patrick C. N
dc.contributor.authorAguilera, Concepción María
dc.contributor.authorLlamas Elvira, José M.
dc.contributor.authorGil, Ángel
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.departmentInstitute on Innovation and Sustainable Development in Food Chain - ISFOODen
dc.date.accessioned2023-03-24T12:45:56Z
dc.date.available2023-03-24T12:45:56Z
dc.date.issued2022
dc.date.updated2023-03-23T09:27:53Z
dc.description.abstractExercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6 ml; Δ MOD-EX: −15.5 ± 62.1 ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1 ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.en
dc.description.sponsorshipThis study was funded by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393; J.R.R.) and PTA-12264I, Retos de la Sociedad (DEP2016-79512-R; J.R.R.) and European Regional Development Funds (ERDF; J.R.R.), the Spanish Ministry of Education (FPU13/04365 (G.S.D.), FPU14/04172 (F.A.G.), FPU15/04059 (J.M.A.), FPU16/03653 (A.M.G.), FPU16/02828 (F.J.O.P.), FPU16/05159 (H.X.), FPU17/01523 (L.O.A.), FPU19/01609 (L.J.F.)), International Doctoral Studies Scholarship no. 440575 from the Mexican National Council of Science and Technology (CONACYT; WDMA), the Fundación Iberoamericana de Nutrición (FINUT; JRR), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022; J.R.R.), the AstraZeneca HealthCare Foundation (J.R.R.), the University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES) (J.R.R.)- and Plan Propio de Investigación 2018 - Programa Contratos-Puente and Programa Perfecionamiento de Doctores (G.S.D.), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR; JRR), the Junta de Andalucía, Consejería de Economía, Conocimiento, Empresas y Universidad (ref. P18-RT-4455; J.R.R.), the Fundación Alfonso Martín Escudero (B.M.T. and G.S.D.), the Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea NextGenerationEU (RR_C_2021_04; B.M.T.), and the Novo Nordisk Foundation (NNF18OC0032394; M.S.).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMartinez-Tellez, B., Sanchez-Delgado, G., Acosta, F. M., Alcantara, J. M. A., Amaro-Gahete, F. J., Martinez-Avila, W. D., Merchan-Ramirez, E., Muñoz-Hernandez, V., Osuna-Prieto, F. J., Jurado-Fasoli, L., Xu, H., Ortiz-Alvarez, L., Arias-Tellez, M. J., Mendez-Gutierrez, A., Labayen, I., Ortega, F. B., Schönke, M., Rensen, P. C. N., Aguilera, C. M., … Ruiz, J. R. (2022). No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nature Communications, 13(1), 5259. https://doi.org/10.1038/s41467-022-32502-xen
dc.identifier.doi10.1038/s41467-022-32502-x
dc.identifier.issn2041-1723
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/44936
dc.language.isoengen
dc.publisherNature Researchen
dc.relation.ispartofNature Communications, 13(1), 1-12en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI13%2F01393/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//DEP2016-79512-R/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU13%2F04365/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU14%2F04172/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU16%2F03653/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU16%2F02828/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU16%2F05159/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU17%2F01523/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MECD//FPU19%2F01609/ES/
dc.relation.publisherversionhttps://doi.org/10.1038/s41467-022-32502-x
dc.rights© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBrown adipose tissueen
dc.subjectExerciseen
dc.subjectYoung sedentary adultsen
dc.titleNo evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trialen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
relation.isAuthorOfPublication81010fc5-9a1b-44dd-8cfe-933acda93159
relation.isAuthorOfPublicationb36e2b1d-3088-4089-806e-fd3040e9583a
relation.isAuthorOfPublication.latestForDiscoveryb36e2b1d-3088-4089-806e-fd3040e9583a

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Martinez_NoEvidence.pdf
Size:
2.2 MB
Format:
Adobe Portable Document Format
Download
Thumbnail Image
Name:
Martinez_NoEvidence_MatCompl.pdf
Size:
2.25 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.78 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artículos de revista ISFOOD - ISFOOD aldizkari artikuluak
Artículos de revista - Aldizkari artikuluak