Changes in muscle power after usual care or early structured exercise intervention in acutely hospitalized older adults

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dc.contributor.authorLópez Sáez de Asteasu, Mikel
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.authorLusa Cadore, Eduardo
dc.contributor.authorCasas Herrero, Álvaro
dc.contributor.authorGalbete Jiménez, Arkaitz
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderGobierno de Navarra / Nafarroako Gobernuaes
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2020-07-02T06:50:29Z
dc.date.available2020-07-02T06:50:29Z
dc.date.issued2020
dc.description.abstractBackground: A classic consequence of short-term bed rest in older adults is the significant loss in skeletal muscle mass and muscle strength that underlies the accelerated physical performance deficits. Structured exercise programmes applied during acute hospitalization can prevent muscle function deterioration. Methods: A single-blind randomized clinical trial conducted in an acute care for elders unit in a tertiary public hospital in Navarre (Spain). Three hundred seventy hospitalized patients [56.5% female patients; mean age (standard deviation) 87.3 (4.9) years] were randomly allocated to an exercise intervention (n = 185) or a control (n = 185) group (usual care). The intervention consisted of a multicomponent exercise training programme performed during 5–7 consecutive days (2 sessions/day). The usual-care group received habitual hospital care, which included physical rehabilitation when needed. The main endpoints were change in maximal dynamic strength (i.e. leg-press, chest-press, and knee extension exercises) and maximal isometric knee extensors and hip flexors strength from baseline to discharge. Changes in muscle power output at submaximal and maximal loads were also measured after the intervention. Results: The physical exercise programme provided significant benefits over usual care. At discharge, the exercise group showed a mean increase of 19.6 kg [95% confidence interval (CI), 16.0, 23.2; P < 0.001] on the one-repetition maximum (1RM) in the leg-press exercise, 5.7 kg (95% CI, 4.7, 6.8; P < 0.001) on the 1RM in the chest-press exercise, and 9.4 kg (95% CI, 7.3, 11.5; P < 0.001) on the 1RM in the knee extension exercise over usual-care group. There were improvements in the intervention group also in the isometric maximal knee extension strength [14.8 Newtons (N); 95% CI, 11.2, 18.5 vs. −7.8 N; 95% CI, −11.0, −3.5 in the control group; P < 0.001] and the hip flexion strength (13.6 N; 95% CI, 10.7, 16.5 vs. −7.2 N; 95% CI, −10.1, −4.3; P < 0.001). Significant benefits were also observed in the exercise group for the muscle power output at submaximal loads (i.e. 30% 1RM, 45% 1RM, 60% 1RM, and 75% 1RM; all P < 0.001) over usual-care group. Conclusions: An individualized, multicomponent exercise training programme, with special emphasis on muscle power training, proved to be an effective therapy for improving muscle power output of lower limbs at submaximal loads and maximal muscle strength in older patients during acute hospitalization.en
dc.description.sponsorshipThis study was funded by a Gobierno de Navarra project grant (Resolución 2186/2014) and acknowledged with the 'Beca Ortiz de Landazuri' for the best research clinical project in 2014, as well as by a research grant PI17/01814 of the Ministerio de Economía, Industria y Competitivad (ISCIII, FEDER). The authors thank Fundación Miguel Servet (Navarrabiomed) for its support during the implementation of the trial, as well as Fundación Caja Navarra and Fundación la Caixa. R.R.-V. is funded in part by a postdoctotal fellowship grant ID 420/2019 of the Public University of Navarre, Spain.en
dc.format.extent10 p.
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1002/jcsm.12564
dc.identifier.issn2190-6009
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/37269
dc.language.isoengen
dc.publisherWileyen
dc.relation.ispartofJournal of Cachexia, Sarcopenia and Muscle, 2020en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//MTM2015-63608-P/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//ECO2015-65031-R/ES/
dc.relation.publisherversionhttps://doi.org/10.1002/jcsm.12564
dc.rights© 2020 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSarcopeniaen
dc.subjectPhysical exerciseen
dc.subjectHospitalizeden
dc.subjectElderlyen
dc.titleChanges in muscle power after usual care or early structured exercise intervention in acutely hospitalized older adultsen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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