Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners

Mendióroz Iriarte, Maite; Puebla Guedea, Marta; Montero Marín, Jesús; Urdánoz Casado, Amaya; Labarga Gutiérrez, Alberto

Publication:
Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners

dc.contributor.author	Mendióroz Iriarte, Maite
dc.contributor.author	Puebla Guedea, Marta
dc.contributor.author	Montero Marín, Jesús
dc.contributor.author	Urdánoz Casado, Amaya
dc.contributor.author	Labarga Gutiérrez, Alberto
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.date.accessioned	2020-08-06T08:35:32Z
dc.date.available	2020-08-06T08:35:32Z
dc.date.issued	2020
dc.description.abstract	Mindfulness and meditation techniques have proven successful for the reduction of stress and improvement in general health. In addition, meditation is linked to longevity and longer telomere length, a proposed biomarker of human aging. Interestingly, DNA methylation changes have been described at specific subtelomeric regions in long-term meditators compared to controls. However, the molecular basis underlying these beneficial effects of meditation on human health still remains unclear. Here we show that DNA methylation levels, measured by the Infinium HumanMethylation450 BeadChip (Illumina) array, at specific subtelomeric regions containing GPR31 and SERPINB9 genes were associated with telomere length in long-term meditators with a strong statistical trend when correcting for multiple testing. Notably, age showed no association with telomere length in the group of long-term meditators. These results may suggest that long-term meditation could be related to epigenetic mechanisms, in particular gene-specific DNA methylation changes at distinct subtelomeric regions.	en
dc.description.sponsorship	The project has received funding from the Network for Prevention and Health Promotion in primary Care (RD12/0005 and RD16/0007/0005) grant and a FIS grant (PI16/00962) from the Instituto de Salud Carlos III of the Spanish Ministry of Economy and Competitiveness, co-financed with European Union ERDF funds. MM has received a grant 'intensificación' from Fundación LaCaixa.	en
dc.format.extent	12 p.
dc.format.mimetype	application/pdf	en
dc.identifier.doi	10.1038/s41598-020-61241-6
dc.identifier.issn	2045-2322
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/37750
dc.language.iso	eng	en
dc.publisher	Nature Research	en
dc.relation.ispartof	Scientific Reports, 2020, 10 (1):4564	en
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//AGL2015-70584-C2-2-R/ES/	en
dc.relation.publisherversion	https://doi.org/10.1038/s41598-020-61241-6
dc.rights	© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject	Biomarkers	en
dc.subject	DNA methylation	en
dc.subject	Mindfulness	en
dc.subject	Meditation	en
dc.title	Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners	en
dc.type	info:eu-repo/semantics/article
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dspace.entity.type	Publication
relation.isAuthorOfPublication	c0cb79d9-6664-4b47-bcd1-b7cb133d224e
relation.isAuthorOfPublication	1d1bfb61-da54-4d1b-a8b3-e669a4b98016
relation.isAuthorOfPublication.latestForDiscovery	c0cb79d9-6664-4b47-bcd1-b7cb133d224e