Muscular strength as a predictor of all-cause mortality in an apparently healthy population: a systematic review and meta-analysis of data from approximately 2 million men and women

dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.authorCavero-Redondo, Iván
dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorLee, Duck-Chul
dc.contributor.authorMartínez Vizcaíno, Vicente
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2025-01-07T13:35:46Z
dc.date.available2025-01-07T13:35:46Z
dc.date.issued2018-09-25
dc.date.updated2025-01-07T13:28:06Z
dc.description.abstractObjectives: The aims of the present systematic review and meta-analysis were to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in an apparently healthy population. Data Sources: Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. Study Selection: Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in an apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies. Data Extraction: Two authors independently extracted data. Data Synthesis: Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR=0.69; 95% CI, 0.64-0.74) compared with lower muscular strength, with a slightly stronger association in women (HR=0.60; 95% CI, 0.51-0.69) than men (HR=0.69; 95% CI, 0.62-0.77) (all P<.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR=0.86: 95% CI, 0.80-0.93; P<.001) compared with adults with lower muscular strength. Conclusions: Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of age and follow-up period. Muscular strength tests can be easily performed to identify people with lower muscular strength and, consequently, with an increased risk of mortality.en
dc.description.sponsorshipFunding for A.G.H. was provided by Banco Santander, SA through program "Becas Iberoamérica ca. Jóvenes Profesores Investigadores. Santander Universidades 2016".
dc.format.mimetypeapplication/pdfen
dc.identifier.citationGarcía-Hermoso, A., Cavero-Redondo, I., Ramírez-Vélez, R., Ruiz, J. R., Ortega, F. B., Lee, D. C., Martínez-Vizcaíno, V. (2018) Muscular strength as a predictor of all-cause mortality in an apparently healthy population: a systematic review and meta-analysis of data from approximately 2 million men and women. Archives of Physical Medicine and Rehabilitation, 99(10), 2100-2113. https://doi.org/10.1016/j.apmr.2018.01.008.
dc.identifier.doi10.1016/j.apmr.2018.01.008
dc.identifier.issn0003-9993
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/52825
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofArchives of Physical Medicine and Rehabilitation, 99(10), 2100-2113
dc.relation.publisherversionhttps://doi.org/10.1016/j.apmr.2018.01.008
dc.rights© 2018 by the American Congress of Rehabilitation Medicine. This manuscript version is made available under the CC-BY-NC-ND 4.0.
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDeathen
dc.subjectHand strengthen
dc.subjectLeg strengthen
dc.subjectMusclesen
dc.titleMuscular strength as a predictor of all-cause mortality in an apparently healthy population: a systematic review and meta-analysis of data from approximately 2 million men and womenen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
relation.isAuthorOfPublicatione84ae68a-fa4a-4e00-be27-bedfffc8612e
relation.isAuthorOfPublicationd0c2c11e-01d0-46ff-93b4-36b11beaf269
relation.isAuthorOfPublication.latestForDiscoverye84ae68a-fa4a-4e00-be27-bedfffc8612e

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