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dc.creatorFaus, Isabeles_ES
dc.creatorZabalza Aznárez, Anaes_ES
dc.creatorSantiago, Juliaes_ES
dc.creatorNebauer, Sergio G.es_ES
dc.creatorRoyuela Hernando, Mercedeses_ES
dc.creatorSerrano, Ramónes_ES
dc.creatorGadea, Josées_ES
dc.date.accessioned2015-10-27T08:36:35Z
dc.date.available2015-10-27T08:36:35Z
dc.date.issued2015
dc.identifier.issn1471-2229
dc.identifier.urihttps://hdl.handle.net/2454/18633
dc.descriptionIncluye 7 ficheros de datoses_ES
dc.description.abstractBackground: The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified. Results: In this study, we identify the protein kinase GCN2 as a cellular component that fosters the action of glyphosate in the model plant Arabidopsis thaliana. Comparative studies using wild-type and gcn2 knock-out mutant seedlings show that the molecular programme that the plant deploys after the treatment with the herbicide, is compromised in gcn2. Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate. Conclusions: These results points to an unknown GCN2-dependent factor involved in the cascade of events triggered by glyphosate in plants. Data suggest either that the herbicide does not equally reach the target-enzyme in a gcn2 background, or that a decreased flux in the shikimate pathway in a gcn2 plants minimize the impact of enzyme inhibition.en
dc.description.sponsorshipThis work was mainly supported by the Universidad Politecnica de Valencia (PAID2011-16) and the Ministerio Español de Ciencia y Tecnología (BFU2011-22526). The work was partially supported through a grant from the Ministerio Español de Ciencia y Tecnología (AGL-2010-18621).en
dc.format.mimetypeapplication/pdfen
dc.format.mimetypeapplication/zipen
dc.language.isoengen
dc.publisherBioMed Centralen
dc.relation.ispartofBMC Plant Biology 2015, 15:14en
dc.rights© 2015 Faus et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectGlyphosateen
dc.subjectGCN2en
dc.subjectTranscriptomicen
dc.subjectShikimateen
dc.subjectTranslationen
dc.subjectHerbicidesen
dc.subjectHorseweed conyza-canadensisen
dc.subjectSugar-beet leavesen
dc.subjectHerbicide resistanceen
dc.subjectVacuolar sequestrationen
dc.subjectPhosphate transporteren
dc.subjectGene expressionen
dc.subjectThalianaen
dc.subjectStressen
dc.subjectEIF2-alphaen
dc.subjectWheaten
dc.titleProtein kinase GCN2 mediates responses to glyphosate in Arabidopsisen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Ciencias del Medio Naturales_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Natura Ingurunearen Zientziak Sailaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1186/s12870-014-0378-0
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/BFU2011-22526en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/AGL2010-18621en
dc.relation.publisherversionhttps://dx.doi.org/10.1186/s12870-014-0378-0
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.type.versionVersión publicada / Argitaratu den bertsioaes


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© 2015 Faus et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as © 2015 Faus et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.