Established and proposed roles of xanthine oxidoreductase in oxidative and reductive pathways in plants

Date

2014

Authors

Esteban Terradillos, Raquel
Bittner, Florian

Director

Publisher

Springer
Acceso abierto / Sarbide irekia
Capítulo de libro / Liburuen kapitulua
Versión aceptada / Onetsi den bertsioa

Project identifier

Impacto
OpenAlexGoogle Scholar
No disponible en Scopus

Abstract

Xanthine oxidoreductase (XOR) is among the most-intensively studied enzymes known to participate in the consumption of oxygen in cells. However, it attracted the attention of researchers due its participation in free radical production in vivo, mainly through the production of superoxide radicals. In plants, XOR is a key enzyme in purine degradation where it catalyzes the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. Both reactions are accompanied by electron transfer to either NAD+ with simultaneous formation of NADH or to molecular oxygen, which results in formation of superoxides. Characterization of plant XOR mutants and isolated XOR proteins from various plant species provided evidence that the enzyme plays significant roles in plant growth, leaf senescence, fruit size, synthesis of nitrogen storage compounds, and plant-pathogen interactions. Moreover, the ability of XOR to carry out redox reactions as NADH oxidase and to produce reactive oxygen species and nitric oxide, together with a possible complementary role in abscisic acid synthesis have raised further attention on the importance of this enzyme. Based on these established and proposed functions, XOR is discussed as regulator of different processes of interest in plant biology and agriculture.

Description

Keywords

Xanthine oxidoreductase, Enzymes, Superoxide radicals, Purine degradation

Department

IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua

Faculty/School

Degree

Doctorate program

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