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Genetic tools derived from Staphylococcus aureus for biotechnological applications in Gram-positive bacteria
(2021)
info:eu-repo/semantics/doctoralThesis,
Staphylococcus aureus is a versatile human pathogen that has emerged as one of the most successful infectious agents of recent times, able to cause a range of diseases including skin and soft tissue infections, endocarditis, ...
Noncontiguous operon atlas in Staphylococcus aureus
(2023)
info:eu-repo/semantics/doctoralThesis,
In previous work from the group, we described the existence of a new transcriptional
architecture that we call a noncontiguous operon (NcO). NcOs consist of groups of
genes that are transcribed on the same RNA molecule, ...
Staphylococcus aureus susceptibility to complestatin and corbomycin depends on the VraSR two-component system
(American Society for Microbiology, 2023)
Artículo / Artikulua,
The overuse of antibiotics in humans and livestock has driven the emergence and spread of antimicrobial resistance and has therefore prompted research
on the discovery of novel antibiotics. Complestatin (Cm) and corbomycin ...
lnsights into bacterial functional amyloids using the staphyiococcal Bap protein asan amyloid model
(2022)
info:eu-repo/semantics/doctoralThesis,
Los arniloides funcionales son componentes clave de la matriz del biofilrn de muchas bacterias. Estas estructuras proporcionan resistencia a las proteasas y a condiciones adversas de desnaturalización, y refuerzan y dan ...
Inhibiting the two‑component system GraXRS with verteporfin to combat Staphylococcus aureus infections
(Nature Research, 2020)
Artículo / Artikulua,
Infections caused by Staphylococcus aureus pose a serious and sometimes fatal health issue. With the
aim of exploring a novel therapeutic approach, we chose GraXRS, a Two-Component System (TCS)
that determines bacterial ...
Antibiofilm activity of flavonoids on staphylococcal biofilms through targeting BAP amyloids
(Nature Research, 2020)
info:eu-repo/semantics/article,
The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the ...
Novel strategies for treating biofilm and MRSA associated infections
(2021)
info:eu-repo/semantics/doctoralThesis,
En esta tesis hemos trabajado en dos estrategias, un cribado fenotípico y
otro frente a una diana específica, que podrían ayudar a ampliar las alternativas
terapéuticas frente a S. aureus. En el primer capítulo, nos hemos ...
Polymicrobial infections: do bacteria behave differently depending on their neighbours?
(Taylor & Francis, 2018)
info:eu-repo/semantics/other,
Despite the number of examples that correlate interspecies interactions in polymicrobial infections with variations in pathogenicity and antibiotic susceptibility of individual organisms, antibiotic therapies are selected ...
Role of sodium salicylate in Staphylococcus aureus quorum sensing, virulence, biofilm formation and antimicrobial susceptibility
(Frontiers Media, 2022)
Artículo / Artikulua,
The widespread threat of antibiotic resistance requires new treatment options. Disrupting bacterial communication, quorum sensing (QS), has the potential to reduce pathogenesis by decreasing bacterial virulence. The aim ...
Bacterial biofilm functionalization through Bap amyloid engineering
(Springer Nature, 2022)
Artículo / Artikulua,
Biofilm engineering has emerged as a controllable way to fabricate living structures with programmable functionalities. The amyloidogenic proteins comprising the biofilms can be engineered to create self-assembling ...