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Tackling the biological meaning of the human olfactory bulb dyshomeostatic proteome across neurological disorders: an integrative bioinformatic approach
Cartas-Cejudo, Paz; Lachén Montes, Mercedes
; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2021)
Artículo / Artikulua 
Olfactory dysfunction is considered an early prodromal marker of many neurodegenerative diseases. Neuropathological changes and aberrant protein aggregates occur in the olfactory bulb (OB), triggering a tangled cascade of ... -
Tailored prevention of functional decline through a multicomponent exercise program in hospitalized oncogeriatric patients: study protocol for a randomized clinical trial
Martínez Velilla, Nicolás; Arrazubi, Virginia; Zambom Ferraresi, Fabíola ; Morilla Ruiz, Idoia; López Sáez de Asteasu, Mikel; Ramírez Vélez, Robinson; Zambom Ferraresi, Fabrício ; Casa Marín, Antón de la; Ollo Martínez, Iranzu; Gorospe-García, Itziar; Gurruchaga Sotés, Ibon; Galbete Jiménez, Arkaitz ; Cedeño Veloz, Bernardo Abel; Martín-Nevado, L.; Izquierdo Redín, Mikel; Vera García, Ruth (Elsevier, 2023)
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BACKGROUND: Cancer mostly affects older adults, causing a wide variety of diagnostic and therapeutic dilemmas. One of the most important moments in cancer patients is the hospitalization period, in which older patients ... -
Targeting fatty acid-binding protein 4 improves pathologic features of aortic stenosis
(MDPI, 2022) Artículo / Artikulua
Aortic stenosis (AS) is a fibrocalcific disease of the aortic valves (AVs). Sex-differences in AS pathophysiology have recently been described. High levels of fatty acid-binding protein 4 (FAPB4) in atherosclerotic plaques ... -
Targeting key players of neuroendocrine differentiation in prostate cancer
Zamora Álvarez, Irene; Freeman, Michael R.; Encío Martínez, Ignacio ; Rotinen Díaz, Mirja Sofia (MDPI, 2023)
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Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PC) that commonly emerges through a transdifferentiation process from prostate adenocarcinoma and evades conventional therapies. ... -
Task failure during exercise to exhaustion in normoxia and hypoxia is due to reduced muscle activation caused by central mechanisms while muscle metaboreflex does not limit performance
Torres Peralta, Rafael; Morales Alamo, David; González Izal, Miriam; Losa Reyna, José; Izquierdo Redín, Mikel (Frontiers, 2016)
Artículo / Artikulua
To determine whether task failure during incremental exercise to exhaustion (IE) is principally due to reduced neural drive and increased metaboreflex activation eleven men (22 ± 2 years) performed a 10 s control isokinetic ... -
La técnica de Nyhus en la reparación de las hernias inguinales recidivadas: análisis de una serie de 203 pacientes
Rico, Aida; Blázquez Lautre, Lucas; Sebastián Labayen, José Luis; Montón Condón, Soledad; Otegi Altolagirre, Joseba Ibai; Docio Gregorio, Gorka (Sociedad Hispanoamericana de Hernia, 2021)
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Introducción y objetivo: la elección de una técnica para el tratamiento de las hernias inguinocrurales recidivadas resulta controvertida por la variabilidad de abordajes y opciones técnicas. Presentamos los casos de hernia ... -
Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners
Mendióroz Iriarte, Maite; Puebla Guedea, Marta; Montero Marín, Jesús; Urdánoz Casado, Amaya ; Labarga, Alberto (Nature Research, 2020)
Artículo / Artikulua
Mindfulness and meditation techniques have proven successful for the reduction of stress and improvement in general health. In addition, meditation is linked to longevity and longer telomere length, a proposed biomarker ... -
Teoría de la mente en los subtipos del trastorno por déficit de atención e hiperactividad
Asiáin Rubio, Patricia; Tirapu Ustárroz, Javier; López-Goñi, José Javier ; Melero Pérez, Ruth (ISEP, 2013)
Artículo / Artikulua
Introducción: el Trastorno por Déficit de Atención e Hiperactividad (TDAH) es el trastorno del neurodesarrollo más frecuente en la infancia con una prevalencia estimada de entre un 3% y un 8%. Sus consecuencias más apreciables ... -
Terapia sistémica breve en personas expuestas a un evento altamente estresante reciente: Un ensayo controlado aleatorizado
Concha Ponce, Pablo; García, Felipe E.; Beyebach, Mark ; Aravena, Valentina (Sociedad Chilena de Psicología Clínica, 2022)
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Antecedentes: Los eventos altamente estresantes pueden tener efectos nocivos en el bienestar y salud mental en las personas. Objetivo: Evaluar la eficacia de un protocolo de intervención preventiva basado en la ... -
A themed game to learn about nursing theories and models: a descriptive study
San Martín Rodríguez, Leticia ; Escalada Hernández, Paula ; Soto Ruiz, María Nelia (Elsevier, 2020)
Artículo / Artikulua
One of the most demanding challenges for teachers in undergraduate nursing programmes is teaching the intangible aspects of the discipline, such as its conceptual and theoretical bases. This study aimed to evaluate nursing ... -
Theory based capacity building intervention for intersectoral action for health at local governments: an exploratory pilot study
Hernantes Colias, Naia; Bermejo-Martins, Elena; Øvergård, Kjell Ivar; Pumar Méndez, María Jesús ; López de Dicastillo Sáinz de Murieta, Olga ; Iriarte Roteta, Andrea ; Antoñanzas Baztán, Elena ; Mujika Zabaleta, Agurtzane (Wiley, 2022)
Artículo / Artikulua
Aim: To design, implement and evaluate a nurse- led capacity building intervention (PromoGOB) for intersectoral action for health at local governments. Design: The programme was based on theories of the policy process and ... -
Thermal characterization, polymorphism, and stability evaluation of Se-NSAID derivatives with potent anticancer activity
Ramos Inza, Sandra; Almagro, Eneko; Font, María; Encío Martínez, Ignacio ; Plano, Daniel; Sanmartín, Carmen; Sirera, Rafael; Lizarraga, Elena (Springer, 2024)
Artículo / Artikulua
Stability, thermal characterization, and identification of possible polymorphism are relevant in the development of novel therapeutic drugs. In this context, thirty new nonsteroidal anti-inflammatory drug (NSAID) derivatives ... -
Time trends and inequalities of physical activity domains and sitting time in South America
(International Society of Global Health, 2022) Artículo / Artikulua
Background: we aimed to investigate time trends and inequalities of different physical activity (PA) domains and sitting time (ST) in adults from South American countries. Methods: we included cross-sectional data of ... -
Time-restricted eating and supervised exercise for improving hepatic steatosis and cardiometabolic health in adults with obesity: protocol for the TEMPUS randomised controlled trial
Camacho-Cardenosa, Alba; Clavero-Jimeno, Antonio; Martín-Olmedo, Juan J.; Amaro Gahete, Francisco J.; Cupeiro, Rocío; González Cejudo, María Trinidad; García Pérez, Patricia Virginia; Hernández-Martínez, Carlos; Sevilla-Lorente, Raquel; O, Alejandro de la; López-Vázquez, Alejandro; Molina-Fernández, Marcos; Carneiro-Barrera, Almudena; García, Federico; Rodríguez-Nogales, Alba; Gálvez Peralta, Julio Juan; Cabeza Laguna, Rafael ; Martín-Rodríguez, José L.; Muñoz-Garach, Araceli; Muñoz Torres, Manuel; Labayen Goñi, Idoia ; Ruiz, Jonatan R. (BMJ Publishing Group, 2024)
Artículo / Artikulua
Introduction. Metabolic dysfunction-associated steatotic liver disease is a major public health problem considering its high prevalence and its strong association with extrahepatic diseases. Implementing strategies based ... -
TNF-α-secreting tumor-infiltrated monocytes play a pivotal role during anti-PD-L1 immunotherapy
Zuazo Ibarra, Miren ; Ridder, Kirsten de; Locy, Hanne; Piccioni, Elisa; Awad, Robin Maximilian; Verhulst, Stefaan; Van Bulck, Mathias; Vlaeminck, Yannick de; Lecoq, Quentin; Reijimen, Eva; Mey, Wout de; Beck, Lien de; Ertveldt, Thomas; Pintelon, Isabel; Timmermans, Jean-Pierre; Escors Murugarren, David; Keyaerts, Marleen; Breckpot, Karine; Goyvaerts, Cleo (Frontiers Media, 2022)
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Immune checkpoint blockade (ICB) of the PD-1 pathway revolutionized the survival forecast for advanced non-small cell lung cancer (NSCLC). Yet, the majority of PD-L1+ NSCLC patients are refractory to anti-PD-L1 therapy. ... -
Top 10 international priorities for physical fitness research and surveillance among children and adolescents: a twin-panel Delphi study
Lang, Justin J.; Zhang, Kai; Agostinis-Sobrinho, César; Andersen, Lars Bo; Basterfield, Laura; Berglind, Daniel; Blain, Dylan O.; Cadenas-Sánchez, Cristina ; Cameron, Christine; Carson, Valerie; Colley, Rachel C.; Csányi, Tamás; Faigenbaum, Avery D.; García Hermoso, Antonio; Queiroz Ferreira Gomes, Thayse Natacha; Gribbon, Aidan; Janssen, Ian; Jurak, Gregor; Kaj, Mónika; Kidokoro, Tetsuhiro; Lane, Kirstin N.; Liu, Yang; Löf, Marie; Lubans, David R.; Magnussen, Costan G.; Manyanga, Taru; McGrath, Ryan; Mota, Jorge; Olds, Tim; Onywera, Vincent O.; Ortega, Francisco B.; Oyeyemi, Adewale L.; Prince, Stephanie A.; Ramírez Vélez, Robinson; Roberts, Karen C.; Rubín, Lukáš; Servais, Jennifer; Silva, Diego Augusto Santos; Silva, Danilo R.; Smith, Jordan J.; Song, Yi; Stratton, Gareth; Timmons, Brian W.; Tomkinson, Grant R.; Tremblay, Mark S.; Wong, Stephen H. S.; Fraser, Brooklyn J. (Springer, 2022)
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Background The measurement of physical ftness has a history that dates back nearly 200 years. Recently, there has been an increase in international research and surveillance on physical ftness creating a need for setting ... -
Tracking of physical fitness levels from childhood and adolescence to adulthood: a systematic review and meta-analysis
(AME Publishing, 2022) Artículo / Artikulua
Background: prospective and large studies indicate that high physical fitness levels during young are beneficial for health during adulthood. The aim of the study was to investigate the tracking of physical fitness components ... -
Trajectories of 24-h movement guidelines from middle adolescence to adulthood on depression and suicidal ideation: a 22-year follow-up study
(BMC Public Health, 2022) Artículo / Artikulua
Background: The 24-h movement guidelines for youth and adults recommend the specific duration of physical activity, sedentary time, and sleep duration to ensure optimal health, but little is known about its relationship ... -
Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells
Rotinen Díaz, Mirja Sofia ; Villar Bécares, Joaquín ; Celay Leoz, Ion ; Serrano Mendioroz, Irantzu ; Notario, Vicente; Encío Martínez, Ignacio (Elsevier, 2011)
Artículo / Artikulua
Type 11 Hydroxysteroid (17-beta) dehydrogenase (HSD17B11) catalyzes the conversion of 5α-androstan-3α,17β-diol into androsterone suggesting that it may play an important role in androgen metabolism. We previously described ... -
Transdiagnostic model of psychological factors and sex differences in depression in a large sample of Ecuador
Ruisoto, Pablo ; López Guerra, Victor Manuel; López Núñez, Carla; Paladines Costa, María Belén; Sánchez Puertas, Rafael; Pineda Cabrera, Nairoby Jackeline (Asociación Española de Psicología Conductual, 2022)
Artículo / Artikulua
Background/Objective: depression represents a leading cause of disability and a major contributor to the overall global burden of disease with women systematically reporting a higher prevalence than men. This study aimed ...
