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Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma
(BioMed Central, 2006)
Artículo / Artikulua,
Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ...
Synthesis and pharmacological screening of several aroyl and heteroaroyl selenylacetic acid derivatives as cytotoxic and antiproliferative agents
(MDPI, 2009)
Artículo / Artikulua,
The synthesis and cytotoxic activity of a series of twenty six aroyl and heteroaroyl selenylacetic acid derivatives of general formula Ar-CO-Se-CH(2)-COOH or Heterar-CO-Se-CH(2)-COOH are reported. The synthesis was carried ...
New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer
(MDPI, 2020)
info:eu-repo/semantics/article,
Aspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA ...
Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: identification of a Se-indomethacin analog as a potential therapeutic for breast cancer
(Elsevier, 2022)
Artículo / Artikulua,
A total of twenty-five novel carboxylic acid, methylester, methylamide or cyano nonsteroidal anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of selenoester were reported. Twenty Se-NSAID ...
Antidiabetic effects of Pediococcus acidilactici pA1c on HFD-induced mice
(MDPI, 2022)
info:eu-repo/semantics/article,
Prediabetes (PreD), which is associated with impaired glucose tolerance and fasting blood glucose, is a potential risk factor for type 2 diabetes mellitus (T2D). Growing evidence suggests the role of the gastrointestinal ...
PD-L1 as a prognostic factor in early-stage colon carcinoma within the immunohistochemical molecular subtype classification
(MDPI, 2021)
Artículo / Artikulua,
Colorectal cancer (CRC) is a very heterogeneous disease. Efforts to characterize and search for biomarkers for these patients are currently ongoing in the hope of establishing a more targeted therapeutic approach. The role ...
Pediococcus acidilactici pA1c® improves the beneficial effects of metformin treatment in type 2 diabetes by controlling glycaemia and modulating intestinal microbiota
(MDPI, 2023)
Artículo / Artikulua,
Type 2 diabetes (T2D) is a complex metabolic disease, which involves maintained hyperglycemia, mainly due to the development of an insulin resistance process. Metformin administration
is the most prescribed treatment for ...
Unveiling a new selenocyanate as a multitarget candidate with anticancer, antileishmanial and antibacterial potential
(MDPI, 2022)
Artículo / Artikulua,
Currently, cancer, leishmaniasis and bacterial infections represent a serious public health burden worldwide. Six cinnamyl and benzodioxyl derivatives incorporating selenium (Se) as selenocyanate, diselenide, or selenide ...
Novel methylselenoesters as antiproliferative agents
(MDPI, 2017)
Artículo / Artikulua,
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ...
Novel acylselenourea derivatives: dual molecules with anticancer and radical scavenging activity
(MDPI, 2023)
Artículo / Artikulua,
Oxidative stress surrounding cancer cells provides them with certain growth and survival advantages necessary for disease progression. In this context, Se-containing molecules have gained attention due to their anticancer ...