Now showing items 1-4 of 4

    • Beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus 

      Maiques, Elisa; Ubeda, Carles; Campoy Sánchez, Susana; Salvador, Noelia; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Barbé, Jordi; Penadés, José R. (American Society for Microbiology, 2006)   Artículo / Artikulua  OpenAccess
      Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer ...
    • Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands 

      Tormo Más, María Ángeles; Mir, Ignacio; Shrestha, Archana; Tallent, Sandra M.; Campoy Sánchez, Susana; Lasa Uzcudun, Íñigo Upna; Barbé, Jordi; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Nature Research, 2010)   Artículo / Artikulua  OpenAccess
      Staphylococcal superantigen-carrying pathogenicity islands (SaPIs) are discrete, chromosomally integrated units of ∼15 kilobases that are induced by helper phages to excise and replicate. SaPI DNA is then efficiently ...
    • Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica 

      Medina-Ruiz, Laura; Campoy Sánchez, Susana; Latasa Osta, Cristina Upna; Cardenas, Paula; Alonso, Juan Carlos; Barbé, Jordi (American Society for Microbiology, 2010)   Artículo / Artikulua  OpenAccess
      Transcription of the Salmonella enterica recA gene is negatively controlled by the LexA protein, the repressor of the SOS response. The introduction of a mutation (recAo6869) in the LexA binding site, in the promoter region ...
    • RinA controls phage-mediated packaging and transfer of virulence genes in gram-positive bacteria 

      Ferrer, María Desamparados; Quiles Puchalt, Nuria; Harwich, Michael D.; Tormo Más, María Ángeles; Campoy Sánchez, Susana; Barbé, Jordi; Lasa Uzcudun, Íñigo Upna; Novick, Richard P.; Christie, Gail E.; Penadés, José R. (Oxford University Press, 2011)   Artículo / Artikulua  OpenAccess
      Phage-mediated transfer of microbial genetic elements plays a crucial role in bacterial life style and evolution. In this study, we identify the RinA family of phage-encoded proteins as activators required for transcription ...