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dc.creatorAlfonso Ruiz, Leopoldoes_ES
dc.date.accessioned2014-05-14T07:34:59Z
dc.date.available2014-05-14T07:34:59Z
dc.date.issued2005
dc.identifier.issn0999-193X (print)
dc.identifier.issn1297-9686 (electronic)
dc.identifier.other853
dc.identifier.urihttps://hdl.handle.net/2454/10528
dc.description.abstractThis article investigates the application of meta-analysis on livestock candidate gene effects. The PvuII polymorphism of the ESR gene is used as an example. The association among ESR PvuII alleles with the number of piglets born alive and total born in the first (NBA1, TNB1) and later parities (NBA, TNB) is reviewed by conducting a meta-analysis of 15 published studies including 9329 sows. Under a fixed effects model, litter size values were significantly lower in the "AA" genotype groups when compared with "AB" and "BB" homozygotes. Under the random effects model, the results were similar although differences between "AA" and "AB" genotype groups were not clearly significant for NBA and TNB. Nevertheless, the most noticeable results was the high and significant heterogeneity estimated among studies. This heterogeneity could be assigned to error sampling, genotype by environment interaction, linkage or epistasis, as referred to in the literature, but also to the hypothesis of population admixture/stratification. It is concluded that meta-analysis can be considered as a helpful analytical tool to synthesise and discuss livestock candidate gene effects. The main difficulty found was the insufficient information on the standard errors of the estimated genotype effects in several publications. Consequently, the convenience of publishing the standard errors or the concrete P-values instead of the test significance level should be recommended to guarantee the quality of candidate gene effect meta-analyses.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherEDP Sciencesen
dc.relation.ispartofGenetics Selection Evolution, 2005, 37 (4). Págs. 417-435en
dc.rights© INRA, EDP Sciences, 2005en
dc.subjectMeta analysisen
dc.subjectCandidate geneen
dc.subjectEstrogen receptorsen
dc.subjectLitter sizeen
dc.subjectPigsen
dc.subjectQuantitative trait locien
dc.subjectEstrogen receptor locusen
dc.subjectPopulation admixtureen
dc.subjectReproductive traitsen
dc.subjectPlacental traitsen
dc.subjectComplex traitsen
dc.subjectPig breedsen
dc.subjectLandraceen
dc.subjectGenotypesen
dc.subjectSwineen
dc.titleUse of meta-analysis to combine candidate gene association studies: application to study the relationship between the ESR PvuII polymorphism and sow litter sizeen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.contributor.affiliationUniversidad Pública de Navarra. Departamento de Producción Agrariaes_ES
dc.contributor.affiliationNafarroako Unibertsitate Publikoa. Nekazaritza Ekoizpena Sailaeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.doi10.1051/gse:2005009
dc.relation.publisherversionhttps://dx.doi.org/10.1051/gse:2005009
dc.type.versionVersión aceptada / Onetsi den bertsioaes
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen


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