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dc.creatorBardají Goikoetxea, Leirees_ES
dc.creatorEcheverría Ancín, Myriames_ES
dc.creatorRodríguez Palenzuela, Pabloes_ES
dc.creatorMartínez García, Pedro M.es_ES
dc.creatorMurillo Martínez, Jesúses_ES
dc.date.accessioned2017-04-10T14:31:37Z
dc.date.available2017-04-10T14:31:37Z
dc.date.issued2017
dc.identifier.issn2045-2322 (Print)
dc.identifier.issn2045-2322 (Electronic)
dc.identifier.urihttps://hdl.handle.net/2454/24088
dc.descriptionIncluye 9 ficheros de datoses_ES
dc.description.abstractIntegrases are a family of tyrosine recombinases that are highly abundant in bacterial genomes, actively disseminating adaptive characters such as pathogenicity determinants and antibiotics resistance. Using comparative genomics and functional assays, we identified a novel type of mobile genetic element, the GInt, in many diverse bacterial groups but not in archaea. Integrated as genomic islands, GInts show a tripartite structure consisting of the ginABCD operon, a cargo DNA region from 2.5 to at least 70 kb, and a short AT-rich 3′ end. The gin operon is characteristic of GInts and codes for three putative integrases and a small putative helix-loop-helix protein, all of which are essential for integration and excision of the element. Genes in the cargo DNA are acquired mostly from phylogenetically related bacteria and often code for traits that might increase fitness, such as resistance to antimicrobials or virulence. GInts also tend to capture clusters of genes involved in complex processes, such as the biosynthesis of phaseolotoxin by Pseudomonas syringae. GInts integrate site-specifically, generating two flanking direct imperfect repeats, and excise forming circular molecules. The excision process generates sequence variants at the element attachment site, which can increase frequency of integration and drive target specificity.en
dc.description.sponsorshipThis work was funded by the Spanish Plan Nacional I+ D+ i grants AGL2011-30343-C02-02 and AGL2014- 53242-C2-2-R, from the Ministerio de Economía y Competitividad (MINECO), co-financed by the Fondo Europeo de Desarrollo Regional (FEDER).en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherNature Publishing Groupen
dc.relation.ispartofScientific Reports 7:46254en
dc.rights© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMobile genetic elementen
dc.subjectPhaseolotoxinen
dc.subjectAntimetabolite toxinen
dc.subjectIntegronsen
dc.subjectVirulence genesen
dc.subjectHorizontal gene transferen
dc.titleFour genes essential for recombination define GInts, a new type of mobile genomic island widespread in bacteriaen
dc.typeArtículo / Artikuluaes
dc.typeinfo:eu-repo/semantics/articleen
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Producción Agrariaes_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Nekazaritza Ekoizpena Sailaeu
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.doi10.1038/srep46254
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/6PN/AGL2011-30343
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/AGL2014-53242
dc.relation.publisherversionhttps://dx.doi.org/10.1038/srep46254
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen


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© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third party material in this article are included in the article’s Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material.
La licencia del ítem se describe como © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.