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dc.creatorChaure, J.es_ES
dc.creatorSerrano, C.es_ES
dc.creatorFernández-Parra, Rocíoes_ES
dc.creatorPeña, Estefaníaes_ES
dc.creatorMalvè, Mauroes_ES
dc.date.accessioned2020-09-22T07:53:10Z
dc.date.available2020-09-22T07:53:10Z
dc.date.issued2016
dc.identifier.issn1573-9686
dc.identifier.urihttps://hdl.handle.net/2454/38156
dc.description.abstractStenting technique is employed worldwide for treating atherosclerotic vessel and tracheal stenosis. Both diseases can be treated by means of metallic stents which present advantages but are affected by the main problem of restenosis of the stented area. In this study we have built a rabbit trachea numerical model and we have analyzed it before and after insertion and opening of two types of commercial stent: a Zilver® FlexTM Stent and a WallStentTM. In experimental parallel work, two types of stent were implanted in 30 New Zealand rabbits divided in two groups of 10 animals corresponding to each stent type and a third group made up of 10 animals without stent. The tracheal wall response was assessed by means of computerized tomography by endoscopy, macroscopic findings and histopathological study 90 days after stent deployment. Three idealized trachea models, one model for each group, were created in order to perform the computational study. The animal model was used to validate the numerical findings and to attempt to find qualitative correlations between numerical and experimental results. Experimental findings such as inflammation, granuloma and abnormal tissue growth, assessed from histomorphometric analyses were compared with derived numerical parameters such as wall shear stress (WSS) and maximum principal stress. The direct comparison of these parameters and the biological response supports the hypothesis that WSS and tensile stresses may lead to a greater tracheal epithelium response within the stented region, with the latter seeming to have the dominant role. This study may be helpful for improving stent design and demonstrates the feasibility offered by in-silico investigated tracheal structural and fluid dynamics.en
dc.description.sponsorshipThis study was supported by the CIBER-BBN financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund and by the Spanish Ministry of Science and Technology through Research Project DPI2013-44391-P; the Department of Industry and Innovation (Government of Aragón) through the research group Grant T88 (Fondo Social Europeo). The experimental study was supported by the Instituto de Salud Carlos III, through research project PI08/1424 and was performed by the Minimally Invasive Techniques Research Group (GITMI) of Aragón Government. The experimental tests have been performed by the ICTS 'NANBIOSIS', more specifically by the Tissue & Scaffold Characterization Unit (U13) of the CIBER in Bioengineering, Biomaterials & Nanomedicne (CIBER-BBN) at the University of Zaragoza.en
dc.format.extent29 p.
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherBiomedical Engineering Societyen
dc.publisherSpringeren
dc.relation.ispartofAnnals of Biomedical Engineering, 2016, 44(2), 368-381en
dc.rights© 2015 Biomedical Engineering Societyen
dc.subjectTracheaen
dc.subjectNitinolen
dc.subjectZilverFlex™ stenten
dc.subjectWallstent™en
dc.subjectFluid-structure interactionen
dc.subjectFinite element methoden
dc.titleOn studying the interaction between different stent models and rabbit tracheal tissue: numerical, endoscopic and histological comparisonen
dc.typeinfo:eu-repo/semantics/articleen
dc.typeArtículo / Artikuluaes
dc.contributor.departmentUniversidad Pública de Navarra. Departamento de Ingeniería Mecánica, Energética y de Materialeses_ES
dc.contributor.departmentNafarroako Unibertsitate Publikoa. Mekanika, Energetika eta Materialen Ingeniaritza Sailaeu
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.rights.accessRightsAcceso abierto / Sarbide irekiaes
dc.identifier.doi10.1007/s10439-015-1504-3
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/1PE/DPI2013-44391-Pen
dc.relation.publisherversionhttps://doi.org/10.1007/s10439-015-1504-3
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.type.versionVersión aceptada / Onetsi den bertsioaes


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