Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls
Fecha
2018Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión aceptada / Onetsi den bertsioa
Identificador del proyecto
Impacto
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10.1016/j.schres.2017.10.035
Resumen
Motor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in
psychosis remains understudied.
This study aimed to examine comparatively the relationships between the whole range of motor abnormalities
and cognitive impairments in the first- ...
[++]
Motor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in
psychosis remains understudied.
This study aimed to examine comparatively the relationships between the whole range of motor abnormalities
and cognitive impairments in the first-episode of psychosis (FEP), their unaffected siblings and healthy control
subjects.
Fifty FEP patients, 21 of their healthy siblings and 24 age- and sex matched healthy controls were included. Motor
assessment included catatonic, extrapyramidal and neurological soft signs (NSS) by means of standardized instruments. An exhaustive neuropsychological battery was also performed to extract the 7 cognitive dimensions
of MATRICS initiative.
Higher scores on NSS but not on extrapyramidal and catatonic signs showed significant associations with worse
cognitive performance in the three study groups. However, the pattern of associations regarding specific cognitive functions was different among the three groups. Moreover, extrapyramidal signs showed significant associations with cognitive impairment only in FEP patients but not in their unaffected siblings and healthy controls.
Catatonic signs did not show any significant association with cognitive functioning in the three study groups.
These findings add evidence to the associations between motor abnormalities, particularly NSS and extrapyramidal signs, and cognitive impairment in first-episode psychosis patients. In addition, our results suggest that the
specific pattern of associations between MAs and cognitive functioning is different in FEP patients from those
of the unaffected siblings and healthy subjects. [--]
Materias
Schizophrenia,
First-episode psychosis,
Unaffected siblings,
First-degree relatives,
Healthy controls,
Neurological assessment,
Catatonia,
Extrapyramidal signs,
Akathisia,
Parkinsonism,
Abnormal movements,
Neurological soft signs,
Cognitive functioning,
Cognitive impairment,
MATRICS
Editor
Elsevier
Publicado en
Schizophrenia Research 200, (2018), 50–55
Departamento
Universidad Pública de Navarra. Departamento de Ciencias de la Salud /
Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila /
Universidad Pública de Navarra. Departamento de Matemáticas /
Nafarroako Unibertsitate Publikoa. Matematika Saila
Versión del editor
Entidades Financiadoras
This work was supported by the Department of Health of the Government of Navarra (grants 55/2007, 11/101 and 87/2014), the Carlos III Health Institute (FEDER Funds) from the Spanish Ministry of Economy and Competitivity (grant 11/02831) and the Spanish Ministry of Science and Innovation (grant SAF2008–05674-C03–02).