Listar Dpto. Ciencias de la Salud - Osasun Zientziak Saila por autor UPNA "González Morales, Andrea"
Mostrando ítems 1-6 de 6
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Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease
The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ... -
Estudio molecular de las células de glioblastoma multiforme tratadas con el adenovirus oncolítico Delta-24-RGD
El tratamiento del glioblastoma multiforme (GBM) con el adenovirus oncolítico Delta-24-RGD, ha demostrado ser seguro y específico. Esta nueva terapia contribuye a la remisión del tumor mediante diversos mecanismos, como ... -
Network-driven proteogenomics unveils an aging-related imbalance in the olfactory IκBα-NFκB p65 complex functionality in Tg2576 Alzheimer’s disease mouse model
Olfaction is often deregulated in Alzheimer’s disease (AD) patients, and is also impaired in transgenic Tg2576 AD mice, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little ... -
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression
Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- ... -
Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy
Adenovirus Delta-24-RGD has shown a remarkable efficacy in a phase I clinical trial for glioblastoma. Delta-24-RGD induces autophagy in glioma cells, however, the molecular derangements associated with Delta-24-RGD infection ... -
Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection
Glioblastoma multiforme (GBM) is the most common and aggressive type of malignant glioma. Oncolytic adenoviruses are being modified to exploit the aberrant expression of proteins in tumor cells to increase the antiglioma ...