Listar Dpto. Ciencias de la Salud - Osasun Zientziak Saila por autor UPNA "Fernández Irigoyen, Joaquín"
Mostrando ítems 1-20 de 46
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Absence of nuclear p16 is a diagnostic and independent prognostic biomarker in squamous cell carcinoma of the cervix
Mendaza Lainez, Saioa
; Fernández Irigoyen, Joaquín 
; Santamaría, Enrique; Zudaire, Tamara; Guarch, Rosa; Guerrero Setas, David (MDPI, 2020)
Artículo / Artikulua 
The tumor-suppressor protein p16 is paradoxically overexpressed in cervical cancer (CC). Despite its potential as a biomarker, its clinical value and the reasons for its failure in tumor suppression remain unclear. Our ... -
Alteration in the cerebrospinal fluid lipidome in Parkinson’s disease: a post-mortem pilot study
Fernández Irigoyen, Joaquín ; Cartas-Cejudo, Paz; Iruarrizaga-Lejarreta, Marta; Santamaría, Enrique (MDPI, 2021)
Artículo / Artikulua
Lipid metabolism is clearly associated to Parkinson’s disease (PD). Although lipid homeostasis has been widely studied in multiple animal and cellular models, as well as in blood derived from PD individuals, the cerebrospinal ... -
Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2020)
Artículo / Artikulua
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ... -
Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
Lozano Vicario, Lucía; García Hermoso, Antonio; Cedeño Veloz, Bernardo Abel; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Romero Ortuno, Román; Zambom Ferraresi, Fabrício ; Sáez de Asteasu, Mikel L.; Muñoz-Vázquez, Ángel Javier; Izquierdo Redín, Mikel; Martínez Velilla, Nicolás (Frontiers Media, 2023)
Artículo / Artikulua
Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the ... -
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior
Herrero-Labrador, Raquel; Fernández Irigoyen, Joaquín ; Vecino, Rebeca; González-Arias, Canela; Ausín, Karina; Crespo, Inmaculada; Fernández Acosta, Francisco J.; Nieto-Estévez, Vanesa; Román, M. José; Perea, Gertrudis; Torres-Alemán, Ignacio; Santamaría, Enrique; Vicario, Carlos (Life Science Alliance, 2023)
Artículo / Artikulua
Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of ... -
Cytokines and lymphoid populations as potential biomarkers in locally and borderline pancreatic adenocarcinoma
González Borja, Iranzu; Viúdez, Antonio; Alors-Pérez, Emilia; Goñi Irigoyen, Saioa ; Amat Villegas, Irene ; Ghanem, Ismael; Pazo-Cid, Roberto; Feliu, Jaime; Alonso, Laura; López López, Carlos; Arrazubi, Virginia; Gallego, Javier; Pérez Sanz, Jairo; Hernández García, Irene; Vera García, Ruth; Castaño, Justo P.; Fernández Irigoyen, Joaquín (MDPI, 2022)
Artículo / Artikulua
Despite its relative low incidence, PDAC is one of the most aggressive and lethal types of cancer, being currently the seventh leading cause of cancer death worldwide, with a 5-year survival rate of 10.8%. Taking into ... -
Deciphering CHFR role in pancreatic ductal adenocarcinoma
González Borja, Iranzu; Alors-Pérez, Emilia; Amat Villegas, Irene; Alonso, Laura; Viyuela-García, Cristina; Goñi Irigoyen, Saioa ; Reyes, José C.; Ceballos-Chávez, María; Hernández García, Irene; Sánchez-Frías, Marina E.; Santamaría, Enrique; Razquin, Socorro; Arjona Sánchez, Álvaro; Arrazubi, Virginia; Pérez Sanz, Jairo; Vera García, Ruth; Fernández Irigoyen, Joaquín ; Castaño, Justo P.; Viúdez, Antonio (Frontiers Media, 2021)
Artículo / Artikulua
Checkpoint with forkhead-associated and ring finger domains (CHFR) has been proposed as a predictive and prognosis biomarker for different tumor types, but its role in pancreatic ductal adenocarcinoma (PDAC) remains unknown. ... -
Deregulated transcription and proteostasis in adult mapt knockout mouse
Andrés Benito, Pol; Flores, África; Busquet-Areny, Sara; Carmona, Margarita; Ausín, Karina; Cartas Cejudo, Paz; Lachén Montes, Mercedes ; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2023)
Artículo / Artikulua
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ... -
Dysregulated protein phosphorylation: a determining condition in the continuum of brain aging and Alzheimer's disease
Ferrer, Isidro; Andrés Benito, Pol; Ausín, Karina; Pamplona, Reinald; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Wiley, 2021)
Artículo / Artikulua
Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ... -
Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease
Lachén Montes, Mercedes ; González Morales, Andrea ; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria ; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Frontiers Media, 2019)
Artículo / Artikulua
The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ... -
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
Cedeño Veloz, Bernardo Abel; Lozano Vicario, Lucía; Zambom Ferraresi, Fabrício ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Rodríguez-García, Alba; Romero Ortuno, Román; Mondragón Rubio, Jaime; Ruiz-Ruiz, Javier; Ramírez Vélez, Robinson; Izquierdo Redín, Mikel; Martínez Velilla, Nicolás (BMC, 2023)
Artículo / Artikulua
Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture ... -
Effectiveness of a multicomponent exercise training program for the management of delirium in hospitalized older adults using near-infrared spectroscopy as a biomarker of brain perfusion: study protocol for a randomized controlled trial
Lozano Vicario, Lucía; Zambom Ferraresi, Fabíola ; Zambom Ferraresi, Fabrício ; Casa Marín, Antón de la; Ollo Martínez, Iranzu; López Sáez de Asteasu, Mikel; Cedeño Veloz, Bernardo Abel; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Romero Ortuno, Román; Izquierdo Redín, Mikel; Martínez Velilla, Nicolás (Frontiers Media, 2022)
Artículo / Artikulua
Delirium is an important cause of morbidity and mortality in older adults admitted to hospital. Multicomponent interventions targeting delirium risk factors, including physical exercise and mobilization, have been shown ... -
Estudio molecular de las células de glioblastoma multiforme tratadas con el adenovirus oncolítico Delta-24-RGD
González Morales, Andrea (2019)
Tesis doctoral / Doktoretza tesia
El tratamiento del glioblastoma multiforme (GBM) con el adenovirus oncolítico Delta-24-RGD, ha demostrado ser seguro y específico. Esta nueva terapia contribuye a la remisión del tumor mediante diversos mecanismos, como ... -
Estudio protALS: análisis proteómico en tejido postmortem de sujetos con Esclerosis Lateral Amiotrofica (ELA): búsqueda de biomarcadores y dianas terapéuticas
(2020) Tesis doctoral / Doktoretza tesia
Esta tesis se centra en la búsqueda de un panel de posibles biomarcadores utilizando la proteómica sobre tejido neurológico humano postmortem como pilar central. La obtención de un biomarcador, que sea objetivo y fácil ... -
Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
Ferrer, Isidro; Andrés Benito, Pol; Zelaya Huerta, María Victoria ; Erro Aguirre, María Elena; Carmona, Margarita; Ausín, Karina; Lachén Montes, Mercedes ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Río, José Antonio del (Springer, 2020)
Artículo / Artikulua
Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, ... -
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit
Belloso Iguerategui, Arantzazu; Zamarbide, Marta; Merino Galán, Leyre; Rodríguez Chinchilla, Tatiana; Gago, Belén; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Cotman, Carl W.; Prieto, G. Aleph; Quiroga Varela, Ana; Rodríguez Oroz, María Cruz (Oxford University Press, 2023)
Artículo / Artikulua
Learning and memory mainly rely on correct synaptic function in the hippocampus and other brain regions. In Parkinson’s disease, subtle cognitive deficits may even precede motor signs early in the disease. Hence, we set ... -
Host tau genotype specifically designs and regulates tau seeding and spreading and host tau transformation following intrahippocampal injection of identical tau AD inoculum
Andrés Benito, Pol; Carmona, Margarita; Jordán, Mónica; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Río, José Antonio del; Ferrer, Isidro (MDPI, 2022)
Artículo / Artikulua
Several studies have demonstrated the different characteristics of tau seeding and spreading following intracerebral inoculation in murine models of tau-enriched fractions of brain homogenates from AD and other tauopathies. ... -
The human gastric juice: a promising source for gastric cancer biomarkers
Felípez, Nayra; Montori, Sheyla; Mendizuri, Naroa; Llach, Joan; Delgado, Pedro G.; Moreira, Leticia; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Albéniz Arbizu, Eduardo (MDPI, 2023)
Artículo / Artikulua
Gastric cancer (GC) is a major public health problem worldwide, with high mortality rates due to late diagnosis and limited treatment options. Biomarker research is essential to improve the early detection of GC. Technological ... -
Improvement of cognitive function in wild-type and Alzheimer's disease mouse models by the immunomodulatory properties of menthol inhalation or by depletion of T regulatory cells
Casares, Noelia; Alfaro Larraya, María; Cuadrado-Tejedor, Mar; Lasarte-Cía, Aritz; Navarro Negredo, Flor; Vivas, Isabel; Espelosín, María; Cartas-Cejudo, Paz; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; García-Osta, Ana; Lasarte, Juan José (Frontiers Media, 2023)
Artículo / Artikulua
A complex network of interactions exists between the olfactory, immune and central nervous systems. In this work we intend to investigate this connection through the use of an immunostimulatory odorant like menthol, analyzing ... -
Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis
Andrés Benito, Pol; Povedano, Mónica; Domínguez Rubio, Raúl; Marco, Carla; Colomina, María J.; López-Pérez, Óscar; Santana, Isabel; Baldeiras, Inês; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2020)
Artículo / Artikulua
Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ...
