• Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis 

      Lachén Montes, Mercedes Upna Orcid; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ...
    • Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease 

      Lachén Montes, Mercedes Upna Orcid; González Morales, Andrea Upna Orcid; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria Upna Orcid; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (Frontiers Media, 2019)   Artículo / Artikulua  OpenAccess
      The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ...
    • The human gastric juice: a promising source for gastric cancer biomarkers 

      Felípez, Nayra; Montori, Sheyla; Mendizuri, Naroa; Llach, Joan; Delgado, Pedro G.; Moreira, Leticia; Santamaría, Enrique; Fernández Irigoyen, Joaquín Upna Orcid; Albéniz Arbizu, Eduardo (MDPI, 2023)   Artículo / Artikulua  OpenAccess
      Gastric cancer (GC) is a major public health problem worldwide, with high mortality rates due to late diagnosis and limited treatment options. Biomarker research is essential to improve the early detection of GC. Technological ...
    • Increased C-X-C motif chemokine ligand 12 levels in cerebrospinal fluid as a candidate biomarker in sporadic amyotrophic lateral sclerosis 

      Andrés Benito, Pol; Povedano, Mónica; Domínguez Rubio, Raúl; Marco, Carla; Colomina, María J.; López-Pérez, Óscar; Santana, Isabel; Baldeiras, Inês; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Sporadic amyotrophic lateral sclerosis (sALS) is a fatal progressive neurodegenerative disease affecting upper and lower motor neurons. Biomarkers are useful to facilitate the diagnosis and/or prognosis of patients and to ...
    • Mass spectrometry-based proteomic profiling of thrombotic material obtained by endovascular thrombectomy in patients with ischemic stroke 

      Muñoz, Roberto; Santamaría, Enrique; Rubio, Idoya; Ausín, Karina; Labarga, Alberto Upna Orcid (MDPI, 2018)   Artículo / Artikulua  OpenAccess
      Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a valuable source of biological information. In this study, we have developed a clinical proteomics workflow to characterize the protein ...
    • Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions 

      Lachén Montes, Mercedes; Mendizuri, Naroa; Ausín, Karina; Echaide Górriz, Míriam; Blanco, Ester; Chocarro, Luisa Upna Orcid; Toro, María de; Escors Murugarren, David; Fernández Irigoyen, Joaquín Upna Orcid; Kochan, Grazyna; Santamaría, Enrique (Frontiers Media, 2022)   Artículo / Artikulua  OpenAccess
      One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ...
    • Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis 

      Colomé, Núria; Abian, Joaquín; Aloria, Kerman; Arizmendi, Jesús M.; Barceló-Batllori, Silvia; Braga-Lagache, Sophie; Burlet-Schiltz, Odile; Carrascal, Montse; Casal, Ignacio J.; Chicano-Gálvez, Eduard; Chiva, Cristina; Clemente, Luis F.; Elortza, Félix; Estanyol, Josep M.; Fernández Irigoyen, Joaquín Upna Orcid; Fernández-Puente, Patricia; Fidalgo, María J.; Froment, Carine; Fuentes, Manuel; Fuentes-Almagro, Carlos; Gay, Marina; Hainard, Alexandre; Heller, Manfred; Hernández, María Luisa; Ibarrola, Nieves; Iloro, Ibon; Kieselbach, Thomas; Lario, Antonio; Locard-Paulet, Marie; Marina-Ramírez, Anabel; Martín, Luna; Morato-López, Esperanza; Muñoz, Javier; Navajas, Rosana; Odena, Antonia M.; Odriozola, Leticia; Oliveira, Eliandre de; Paradela, Alberto; Pasquarello, Carla; Rios, Vivian de los; Ruiz-Romero, Cristina; Sabidó, Eduard; Sánchez del Pino, Manuel; Sancho, Jaime; Santamaría, Enrique; Schaeffer-Reiss, Christine; Schneider, Justine; Torre, Carolina de la; Valero, Luz M.; Vilaseca, Marta; Wu, Shuai; Wu, Linfeng; Ximénez de Embún, Pilar; Canals, Francesc; Corrales, Fernando J.; ProteoRed-ISCIII; EuPA (Elsevier, 2022)   Artículo / Artikulua  OpenAccess
      Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that make ...
    • Neuroanatomical quantitative proteomics reveals common pathogenic biological routes between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) 

      Iridoy Zulet, Marina; Zubiri, Irene; Zelaya Huerta, María Victoria Upna Orcid; Martínez, Leire; Ausín, Karina; Lachén Montes, Mercedes Upna Orcid; Santamaría, Enrique; Fernández Irigoyen, Joaquín Upna Orcid; Jericó Pascual, Ivonne (MDPI, 2019)   Artículo / Artikulua  OpenAccess
      (1) Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with an overlap in clinical presentation and neuropathology. Common and differential mechanisms leading ...
    • New in vivo approach to broaden the thioredoxin family interactome in chloroplasts 

      Ancín Rípodas, María Upna Orcid; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique; Larraya Reta, Luis María Upna Orcid; Fernández San Millán, Alicia Upna Orcid; Veramendi Charola, Jon Upna Orcid; Farrán Blanch, Inmaculada (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Post-translational redox modifications provide an important mechanism for the control of major cellular processes. Thioredoxins (Trxs), which are key actors in this regulatory mechanism, are ubiquitous proteins that catalyse ...
    • Olfactory bulb proteomics reveals widespread proteostatic disturbances in mixed dementia and guides for potential serum biomarkers to discriminate alzheimer disease and mixed dementia phenotypes 

      Lachén Montes, Mercedes Upna Orcid; Íñigo-Marco, Ignacio; Cartas-Cejudo, Paz; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      The most common form of mixed dementia (MixD) is constituted by abnormal protein deposits associated with Alzheimer's disease (AD) that coexist with vascular disease. Although olfactory dysfunction is considered a clinical ...
    • Oncolytic adenovirus Delta-24-RGD induces a widespread glioma proteotype remodeling during autophagy 

      González Morales, Andrea Upna Orcid; Zabaleta, Aintzane; García Moure, Marc; Alonso Roldán, Marta Upna; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (Elsevier, 2018)   Artículo / Artikulua  OpenAccess
      Adenovirus Delta-24-RGD has shown a remarkable efficacy in a phase I clinical trial for glioblastoma. Delta-24-RGD induces autophagy in glioma cells, however, the molecular derangements associated with Delta-24-RGD infection ...
    • Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory-entorhinal-amygdaloid axis in Alzheimer's and Parkinson's diseases 

      Cartas-Cejudo, Paz; Lachén Montes, Mercedes Upna Orcid; Ferrer, Isidro; Fernández Irigoyen, Joaquín; Santamaría, Enrique (BMC, 2023)   Artículo / Artikulua  OpenAccess
      Background Smell impairment is one of the earliest features in Alzheimer’s (AD) and Parkinson’s diseases (PD). Due to sex diferences exist in terms of smell and olfactory structures as well as in the prevalence and ...
    • Spatial and temporal proteome dynamics of glioma cells during oncolytic adenovirus Delta-24-RGD infection 

      González Morales, Andrea Upna Orcid; Zabaleta, Aintzane; Guruceaga, Elizabeth; Alonso Roldán, Marta Upna; García Moure, Marc (Impact Journals, 2018)   Artículo / Artikulua  OpenAccess
      Glioblastoma multiforme (GBM) is the most common and aggressive type of malignant glioma. Oncolytic adenoviruses are being modified to exploit the aberrant expression of proteins in tumor cells to increase the antiglioma ...
    • Tackling the biological meaning of the human olfactory bulb dyshomeostatic proteome across neurological disorders: an integrative bioinformatic approach 

      Cartas-Cejudo, Paz; Lachén Montes, Mercedes Upna Orcid; Fernández Irigoyen, Joaquín Upna Orcid; Santamaría, Enrique (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Olfactory dysfunction is considered an early prodromal marker of many neurodegenerative diseases. Neuropathological changes and aberrant protein aggregates occur in the olfactory bulb (OB), triggering a tangled cascade of ...
    • Towards precision prognostication and personalized therapeutics through proteomics 

      Santamaría, Enrique (MDPI, 2023)   Otros / Bestelakoak  OpenAccess
      Next-generation proteomics has allowed the implementation of biomedical proteome research to uncover disease-affected protein expression profiles. It has also enabled the determination of protein localization, protein ...

      El Repositorio ha recibido la ayuda de la Fundación Española para la Ciencia y la Tecnología para la realización de actividades en el ámbito del fomento de la investigación científica de excelencia, en la Línea 2. Repositorios institucionales (convocatoria 2020-2021).
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